کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374637 981922 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discovery of a novel class of triazolones as Checkpoint Kinase inhibitors—Hit to lead exploration
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Discovery of a novel class of triazolones as Checkpoint Kinase inhibitors—Hit to lead exploration
چکیده انگلیسی

Checkpoint Kinase-1 (Chk1, CHK1, CHEK1) is a Ser/Thr protein kinase that mediates cellular responses to DNA-damage. A novel class of Chk1 inhibitors, triazoloquinolones/triazolones (TZ’s) was identified by high throughput screening. The optimization of these hits to provide a lead series is described.

Checkpoint Kinase-1 (Chk1, CHK1, CHEK1) is a Ser/Thr protein kinase that mediates cellular responses to DNA-damage. A novel class of Chk1 inhibitors, triazoloquinolones/triazolones (TZ’s) was identified by high throughput screening. The optimization of these hits to provide a lead series is described.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 17, 1 September 2010, Pages 5133–5138
نویسندگان
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