کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8545958 | 1561686 | 2018 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
DNA repair mechanisms in response to genotoxicity of warfare agent sulfur mustard
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کلمات کلیدی
BERChk1CEEsTFIIHMMRCHK2FANCD2NHEJSSATLSATRCdc25PARP-1DSBataxia telangiectasia mutated - Ataxia telangiectasia جهش یافته استataxia telangiectasia and Rad3 related - ataxia telangiectasia و Rad3 مرتبط استCDKs - CDK هاNER - DOWNDNA damage - آسیبDNAcheckpoint kinase 1 - بازرسی کیناز 1DNA repair - ترمیم DNAnucleotide excision repair - تعمیر مجدد نوکلئوتیدیmismatch repair - تعمیر ناسازگاریbase excision repair - تعمیر پایه پایهATM - خودپردازcell division cycle 25 - سلول تقسیم سلولی 25translesion synthesis - سنتز ترجمهSulfur mustard - سولفور موستارد یا گاز خردلdouble strand breaks - شکست دو رشتهnon-homologous end joining - عدم پیوستن انتهای غیر همولوگHomologous recombination - نوترکیبی همولوگpoly (ADP-ribose) polymerase-1 - پلی (ADP-ribose) پلیمراز-1cyclin-dependent kinases - کیناز وابسته به سیکلین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Sulfur mustard (SM) is an alkylating agent that causes severe damages to the skin, eyes, and the respiratory system. DNA alkylation is one of the most critical lesions that could lead to monoadducts and cross-links, as well as DNA strand breaks. In response to these adducts, cells initiate a series of reactions to recruit specific DNA repair pathways. The main DNA repair pathways in human cells, which could be involved in the DNA SM-induced DNA damages, are base excision repair (BER), nucleotide excision repair (NER), homologous recombination (HR) and non-homologous end joining (NHEJ). There is, thus, a need for a short review to clarify which damage caused by SM is repaired by which repair pathway. Increasing our knowledge about different DNA repair mechanisms following SM exposure would lay the first step for developing new therapeutic agents to treat people exposed to SM. In this review, we describe the major DNA repair pathways, according to the DNA adducts that can be caused by SM.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 58, March 2018, Pages 230-236
Journal: Environmental Toxicology and Pharmacology - Volume 58, March 2018, Pages 230-236
نویسندگان
Yunes Panahi, Amir Fattahi, Hamid Reza Nejabati, Sina Abroon, Zeinab Latifi, Abolfazl Akbarzadeh, Tohid Ghasemnejad,