Keywords: Particulate matter; PARP-1; β-amyloid; Glial cell; Alzheimer's disease;
مقالات ISI (ترجمه نشده)
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Keywords: Mitochondrial encephalopathy; Ndufs4 knockout mice; Rapamycin; Mitochondria; Mitochondrial diseases; ATP5D; ATP synthase H+ transporting mitochondrial F1 complex delta subunit; Cox1; cytochrome c oxidase I; Cox2; cytochrome c oxidase subunit 2; Cox15; Cyt
Keywords: AIF; apoptosis inducing factor; Ang; angiopoietin; AP-1; activator protein-1; APEX; Assessment of Proteasome Inhibition for Extending Remissions; ATP; adenosine-5â²-triphosphate; BiPN; bortezomib-induced peripheral neuropathy; CiPN; chemotherapy-induced
Keywords: BIR; baculovirus inhibitor of apoptosis protein repeat; Bcl-2; B-cell lymphoma 2; CASP3; caspase-3; CASP9; caspase-9; CYC2; cytochrome c; DMEM; Dulbecco's Modified Eagle Medium; FBS; fetal bovine serum; HCC; human hepatocellular carcinoma; HPRT1; hypoxant
Keywords: Cancer stem cell; Chemotherapy; Chemoresistance; Targeted therapy; 5-FU; 5-fluorouracil; ABCT; ATP-binding cassette transporter; ALDH; Aldehyde dehydrogenase; AML; Acute myeloid leukemia; ASC; Adult stem cell; BCRP or ABCG; Breast cancer resistance protei
Keywords: Chromatin remodeling; DNA damage; Nucleosomes; Glycosylase; AP endonuclease; Polymerase β; Ligase; SNF2; BRG1; PARP-1; SWI/SNF; RSC; ISWI; INO80
Keywords: Algae; Apoptosis; Programmed cell death; Metacaspases; APAF-1; PARP-1;
Keywords: necroptosis; PARP-1; parthanatos; remote lung injury; renal transplantation;
Keywords: DIQ; 1,5-dihydroxyisoquinoline; 4-AN; 4-amino-1,8-naphthalimide; 6,4PPs; 6,4-photoproducts; 8-oxodG; 8-oxo-2â²-deoxyguanosine; OGG1; 8-oxoguanine glycosylase 1; APE1; AP-endonuclease; ATM; ataxia telangiectasia-mutated gene; BER; base excision repair; BR
Keywords: ACS; acyl-CoA synthetase; ACSVL; very-long-chain acyl-CoA synthetase; AP; alkaline phosphatase; AST; aspartate aminotransferase; ATF-2; activating transcription factor-2; Bax; Bcl-2 associated X protein; CE; cholesterol ester; Cer; ceramides; CerS; cerami
Keywords: Glioblastoma; Treatment; Review; Pharmacology; Targeted therapy; Stem cell; AKT; protein kinase B; BBB; blood-brain barrier; BCNU; carmustin; CCNU; lomustin; c-MET; hepatocyte growth factor receptor; EGF(R); epidermal growth factor (receptor); EGFRvIII; e
Keywords: Chromandiones; Cancer cells; Apoptosis; PARP-1; Akt;
Keywords: Colloid; Bacteria; Batch; PARP-1; Column experiments; Porous media; Attachment;
Keywords: AD; Alzheimer's disease; AP site; apurinic/apyrimidinic site; APE1; apurinic/apyrimidinic endonuclease 1; Aβ; amyloid beta; BER; base excision repair; CaMKII; Ca2 +/Calmodulin-Dependent Protein Kinase II; CDK; cyclin-dependent kinase; CREB; cAMP respons
Keywords: Electron transport chain; Amobarbital; PARP-1; Caspase 3; Apoptosis; Harlequin mice;
Keywords: Extracellular alpha-synuclein; Oxidative stress; “Prion-like” protein transmission; Nitric oxide; Mitochondria dysfunction; Neurodegenerative diseases; OH; hydroxyl radicals; AD; Alzheimer's disease; ASN; α-synuclein; Aβ; amyloid β; CaN; calcineu
Keywords: AMPK; 5â²-adenosine monophosphate (AMP)-activated protein kinase; CC; Compound C; DAPI; 4â²,6-diamidino-2-phenylindole; DRG; dorsal root ganglia; E; embryonic day; GSH; glutathione; GSK3β; glycogen synthase kinase 3β; LKB1; serine/threonine kinase 11;
Keywords: Et; ethidium; FJB; fluorojade-B; GR; glutathione reductase; GPx; glutathione peroxidase; MnSOD; manganese-dependent superoxide dismutase; NOX; NADPH oxidase; GSSG; oxidized glutathione; PARP-1; poly-(ADP ribose) polymerase-1; ROS; reactive oxygen species;
SIRT3-mediated cardiac remodeling/repair following myocardial infarction
Keywords: MI; myocardial infarction; HIF; hypoxia inducible factor-1α; SOD2; superoxide dismutase; FOXO3A; forkhead box O3a; OPA1; optic atrophy 1; MMPs; matrix metalloproteinases; TGF-β; transforming growth factor-β; PARP-1; poly (ADP ribose)- polymerase 1; VEG
miR-7-5p overexpression suppresses cell proliferation and promotes apoptosis through inhibiting the ability of DNA damage repair of PARP-1 and BRCA1 in TK6 cells exposed to hydroquinone
Keywords: Hydroquinone; Apoptosis; Cell proliferation; miR-7-5p; PARP-1; BRCA1;
A silyl andrographolide analogue suppresses Wnt/β-catenin signaling pathway in colon cancer
Keywords: CRC; colorectal cancer; TBDPS; tert-butyldiphenylsilyl; GSK-3β; glycogen synthase kinase-3β; TCF/LEF; T-cell factor and lymphoid enhancer factor; PARP-1; poly (ADP-ribose) polymerase-1; Andrographolide analogue; Anti-cancer; Colorectal cancer; Wnt/β-ca
Bioactive constituents from cinnamon, hemp seed and polygonum cuspidatum protect against H2O2 but not rotenone toxicity in a cellular model of Parkinson's disease
Keywords: Cinnamon; Hemp seed; Oxidative stress; Polygonum cuspidatum; Parkinson's disease; Rotenone; DA; Dopamine; DMSO; Dimethyl sulfoxide; GSH; Glutathione; H2O2; Hydrogen peroxide; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetra hydropyridine; MTT; Methylthiazolyldipheny
PARP-1 inhibition attenuates cardiac fibrosis induced by myocardial infarction through regulating autophagy
Keywords: PARP-1; Autophagy; Myocardial infarction; Cardiac fibroblast;
The dual role of poly(ADP-ribose) polymerase-1 in modulating parthanatos and autophagy under oxidative stress in rat cochlear marginal cells of the stria vascularis
Keywords: Oxidative stress; PARP-1; Parthanatos; Autophagy; Marginal cells; Glucose oxidase;
Ormosanine from Akebia quinata suppresses ethanol-induced inflammation and apoptosis and activates antioxidants via the mitogen activated protein kinase signaling pathway
Keywords: Ormosanine; Ethanol-induced liver injury; Inflammation; Apoptosis; Antioxidant enzyme; ABTS; 2,2â²-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid); AQ; Akebia quinata; AST; alanine aminotransferase; ALD; alcoholic liver disease; Bcl-2; B-cell lymphoma
PARP-1 inhibition ameliorates elastase induced lung inflammation and emphysema in mice
Keywords: COPD; Lung inflammation; Emphysema; NF-κB; Olaparib; PARP-1;
Targeting NAD+ degradation: The therapeutic potential of flavonoids for Alzheimer's disease and cognitive frailty
Keywords: Flavonoids; NAD+; PARP-1; CD38; Sirtuins; Alzheimer's disease; Cognitive frailty;
Preliminary evaluation of a novel 18F-labeled PARP-1 ligand for PET imaging of PARP-1 expression in prostate cancer
Keywords: PARP-1; PET imaging; Prostate cancer; Cell uptake; Biodistribution;
Detection of PARP-1 activity based on hyperbranched-poly (ADP-ribose) polymers responsive current in artificial nanochannels
Keywords: PARP-1; PARylation; Anodic aluminum oxide; Electrochemistry; Nanochannel;
DNA repair mechanisms in response to genotoxicity of warfare agent sulfur mustard
Keywords: ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and rad3 related; BER; base excision repair; Cdc25; cell division cycle 25; CDKs; cyclin-dependent kinases; CEES; 2-chloroethyl ethyl sulphide; ChK1; checkpoint kinase 1; Chk2; checkpoint kina
Identification of amentoflavone as a potent highly selective PARP-1 inhibitor and its potentiation on carboplatin in human non-small cell lung cancer
Keywords: Amentoflavone; Parp-1 inhibitor; Lung cancer; Chemosensitizer; A549 cells; PARP-1; the nuclear protein poly (adp-ribose) polymerase-1; AMF; amentoflavone; CBP; carboplatin; NSCLC; non-small cell lung cancer; S. mollendorfii; selaginella mollendorfii; TCM;
Lysosomal permeabilization and endoplasmic reticulum stress mediate the apoptotic response induced after photoactivation of a lipophilic zinc(II) phthalocyanine
Keywords: Ac-LEHD-AMC; Ac-Leu-Glu-His-Asp 7-amino-4-methylcoumarin; BAPTA-AM; 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester); CA-074 Me; (L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester; DiOC
Cytotoxic effect of Kalanchoe flammea and induction of intrinsic mitochondrial apoptotic signaling in prostate cancer cells
Keywords: 2AA; 2-aminoanthracene; 4NQO; 4-nitroquinoline; BCA; bicinchoninic acid; Bcl-2; B-cell lymphoma 2; CA; coumaric acid; CAD; caspase-activated dnase; DAPI; 4',6-diamidino-2-phenylIndole; DCF; oxidize 2'-7'-dichlorodihydrofluorescein; DCFH; reduced 2â
MicroRNA-223 protects neonatal rat cardiomyocytes and H9c2 cells from hypoxia-induced apoptosis and excessive autophagy via the Akt/mTOR pathway by targeting PARP-1
Keywords: MicroRNA-223; Myocardial infarction; Apoptosis; Autophagy; PARP-1; Akt/mTOR signaling pathway;
Autophagy in ischemic stroke
Keywords: 3-MA; 3-methyladenine; Aβ; amyloid β; AIF; apoptosis-inducing factor; Akt; protein kinase B; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; Atg; autophagy-related genes; ATP; adenosine 5â²-triphosphate; BBB; blood-brain ba
Autophagy in hemorrhagic stroke: Mechanisms and clinical implications
Keywords: AIM2; absent in melanoma 2; AMPK; Adenosine 5â² monophosphate-activated protein kinase; ASC; apoptosis-associated speck-like protein containing a CARD; BBB; blood-brain barrier; BH3; Bcl-2 homology 3; BMVECs; brain microvascular endothelial cells; BNIP3;
Extracellular poly(ADP-ribose) is a neurotrophic signal that upregulates glial cell line-derived neurotrophic factor (GDNF) levels in vitro and in vivo
Keywords: PAR; GDNF; PARP-1; Cell death; Parkinson disease; ANOVA; one-way analysis of variance; BDNF; brain-derived neurotrophic factor; DMEM; Dulbecco's modified Eagle medium; ELISA; enzyme-linked immunosorbent assay; EDTA; ethylenediaminetetraacetic acid; EC-PAR
Downregulation of Iduna is associated with AIF nuclear translocation in neonatal brain after hypoxia-ischemia
Keywords: AIF; apoptosis-inducing factor; HI; hypoxiaischemia; PARP-1; poly (ADP-ribose) polymerase-1; Iduna; apoptosis-inducing factor; hypoxia-ischemia; neonatal rats;
Chlorogenic acid complex (CGA7), standardized extract from green coffee beans exerts anticancer effects against cultured human colon cancer HCT-116 cells
Keywords: LDH; lactate dehydrogenase; PARP1; poly(ADP-ribose) polymerase; AO/EO; acridine orange/ethidium bromide; DNA; deoxyribosenucleic acid; Apoptosis; Chlorogenic acid complex; PARP-1; Green coffee beans; DNA fragmentation;
Associations of PARP-1 variant rs1136410 with PARP activities, oxidative DNA damage, and the risk of age-related cataract in a Chinese Han population: A two-stage case-control analysis
Keywords: PARP-1; poly (ADP-ribose) polymerase-1; ARC; age-related cataract; 8-OHdg; 8-hydroxy-2â²-deoxyguanosine; HRM; high-resolution melting; PBMCs; peripheral blood mononuclear cells; PSC; posterior subcapsular; LECs; lens epithelial cells; BER; base excision
Differential sensitivities of cellular XPA and PARP-1 to arsenite inhibition and zinc rescue
Keywords: PARP-1; poly (ADP-ribose) polymerase 1; NER; Nucleotide excision repair; BER; base excision repair; HEKn; Normal neonatal human epidermal keratinocytes; XPA; xeroderma pigmentosum group A; UVR; ultraviolet radiation; (6-4)PP; 6,4-photoproduct; CPD; cyclob
Expression of DNA damage response proteins in cervical cancer patients treated with radical chemoradiotherapy
Keywords: Cervical cancer; Chemoradiotherapy; ATM; PARP-1; DNA-PKcs;
Cancer-derived exosomes as a delivery platform of CRISPR/Cas9 confer cancer cell tropism-dependent targeting
Keywords: CRISPR/Cas9; Gene editing; Cancer therapy, combination therapy; Delivery vehicle; Exosomes; PARP-1; Cisplatin;
Neer Award 2016: reduced muscle degeneration and decreased fatty infiltration after rotator cuff tear in a poly(ADP-ribose) polymerase 1 (PARP-1) knock-out mouse model
Keywords: Basic Science Study; In-Vivo Animal Model; Rotator cuff tear; PARP-1; ARTD1; supraspinatus muscle; knock out mouse model; inflammation; muscle atrophy; fatty infiltration;
Poly(ADP-ribose)polymerase-1 hyperactivation in neurodegenerative diseases: The death knell tolls for neurons
Keywords: PARP-1; Neurodegeneration; PARylation; Mitochondrial dysfunction; AIF translocation; Parthanatos;
Inhibition of autophagy enhances Hydroquinone-induced TK6 cell death
Keywords: Autophagy; Hydroquinone; Apoptosis; 3-MA; CQ; PARP-1;
Role of PARP-1 as a novel transcriptional regulator of MMP-9 in diabetic retinopathy
Keywords: Acetylation; Diabetic retinopathy; MMP-9; PARP-1; Transcriptional regulation;
Enhanced neuroprotection of anthocyanin-loaded PEG-gold nanoparticles against Aβ1-42-induced neuroinflammation and neurodegeneration via the NF-KB /JNK/GSK3β signaling pathway
Keywords: PEG-AuNPs; Amyloid beta; Anthocyanins; Alzheimer's disease; Neurodegeneration; Neuroinflammation; BACE-1; Beta-site APP cleaving enzyme-1; PBS; Phosphate buffer saline; NF-KB; Nuclear factor kappa B; iNOS; Inducible nitric oxide synthase; TNF-α; Tumor ne
XRCC1-mediated repair of strand breaks independent of PNKP binding
Keywords: XRCC1 phosphorylation; PNKP; PARP-1; Tdp1; Top1; Camptothecin; Hydrogen peroxide;
Cytotoxic platinum coordination compounds. DNA binding agents
Keywords: 1,0,1/t,c,t; [{trans-PtCl(NH3)2}2μ-cis-Pt(NH3)2{H2N(CH2)6NH2}2]4+; 1,0,1/t,t,t; trans-PtCl(NH3)2}2μ-trans-Pt(NH3)2{H2N(CH2)6NH2}2]4+ (BBR3464); 1,1/c,c; [{cis-PtCl(NH3)2}2µ-{H2N(CH2)6NH2}]2+; 1,1/c,c,prz; [{cis-Pt(NH3)2}2(µ-OH)(µ-pyrazolato)]2+; 1,1/