دانلود مقالات ISI درباره Parp-1 + ترجمه فارسی

Arsenite-induced ROS/RNS generation causes zinc loss and inhibits the activity of poly(ADP-ribose) polymerase-1

Keywords: ROS; reactive oxygen species; RNS; reactive nitrogen species; PARP-1; poly(ADP ribose) polymerase 1; AG; aminoguanidine; IP; immunoprecipitation; NOS; nitric oxide synthase; ELISA; enzyme-linked immunosorbent assay; EMSA; electrophoretic mobility shift as

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Selective inhibition of tumor necrosis factor-α converting enzyme attenuates liver toxicity in a murine model of concanavalin A induced auto-immune hepatitis

Keywords: TNF-α; TNF-α converting enzyme; Concanavalin A; Autoimmune hepatitis; PARP-1;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Iduna protects HT22 cells from hydrogen peroxide-induced oxidative stress through interfering poly(ADP-ribose) polymerase-1-induced cell death (parthanatos)

Keywords: ROS; Reactive oxygen species; H2O2; hydrogen peroxide; PARP-1; Poly(ADP-ribose) (PAR) polymerase-1; BAF; boc-aspartyl-fmk; AIF; apoptosis inducing factor; PBM; PAR binding motif; siRNA; short interfering RNA; PBS; phosphate buffered saline; LDH; Lactate d

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Immunostimulatory activity of polysaccharides from Cheonggukjang

Keywords: BUN; blood urea nitrogen; CK; creatine kinase; DMEM; Dulbecco's modified Eagle medium; DMSO; dimethyl sulfoxide; DTT; dithiothreitol; ELISA; enzyme linked immunosorbent assay; ERK; extracellular-signal-related kinase; FBS; fetal bovine serum; FST; force

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

Keywords: AGRP; agouti-related protein; AMPK; AMP-activated protein kinase; AP-1; activator protein-1; BCL10; B-cell lymphoma/leukemia-10; CIITA; class II, major histocompatibility complex, transactivator; DHA; docosahexaenoic acid; E2F1; transcription factor E2F1;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs

Keywords: PARP-1; Hurtley reaction; Tandem; Isocoumarin; Isoquinolin-1-one;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Cleavage of poly (ADP-ribose) polymerase-1 is involved in the process of porcine ovarian follicular atresia

Keywords: PARP-1; Cleaved-PARP-1; Caspase-3; Cleaved-caspase-3; Follicular atresia; Porcine;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Cellular NAD depletion and decline of SIRT1 activity play critical roles in PARP-1-mediated acute epileptic neuronal death in vitro

Keywords: Poly(ADP-ribose) polymerase-1; PARP-1; Hippocampal neuronal culture; HNC; Acquired epilepsy; AE; Nicotinamide adenine dinucleotide; NAD; Apoptosis-inducing factor; AIF; Poly(ADP-ribose); PAR; Mitochondrial permeability transition; MPT; Terminal deoxynucle

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration

Keywords: MDA; malondialdehyde; 4-HNE; 4-hydroxynonenal; EAE; experimental allergic encephalomyelitis; MS; mutiple sclerosis; SSB; single strand break; DSB; double strand break; 8-OxoG; 8-hydroxyguanosine; 8-NO(2)-G; 8-nitroguanine; AP; apurinic/apyrmidinic; OGG1;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses

Keywords: DNA polymerase β; XRCC1; PARP-1; Methyl methanesulfonate; PARP inhibitor; Poly(ADP-ribose);

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

DNA-dependent SUMO modification of PARP-1

Keywords: PARP-1; SUMO; Posttranslational modification; DNA binding; DNA repair; Transcription;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

p70S6 kinase is a target of the novel proteasome inhibitor 3,3′-diamino-4′-methoxyflavone during apoptosis in human myeloid tumor cells

Keywords: AML; acute myeloid leukemia; DD1; 3,3′-diamino-4′-methoxyflavone; DNFAA; 2′,3-dinitroflavone-8-acetic acid; 4EBP1; eukaryotic translation initiation factor 4E binding protein 1; FCS; fetal calf serum; FITC; fluorescein isothiocyanate; LPS; lipopolys

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Identification of novel PARP-1 inhibitors by structure-based virtual screening

Keywords: Virtual screening; Docking; PARP-1; Thienopyrimidinone; Isoquinolinoquinazolinone; Cyclopentenothienopyrimidinone;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose)polymerase inhibitors

Keywords: Poly(ADP-ribose)polymerase inhibitors; PARP-1; Structure-based drug design; 1,4-Benzoxazin-3-one; Chemopotentiation

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Effect of repetitive daily ethanol intoxication on adult rat brain: Significant changes in phospholipase A2 enzyme levels in association with increased PARP-1 indicate neuroinflammatory pathway activation

Keywords: Alcohol; Neuroinflammation; PLA2; AQP4; Neurodegeneration; Arachidonic acid; PARP-1; ParthanatosAA, arachidonic acid; AQP4, aquaporin-4; DHA, docosahexaenoic acid; EC, entorhinal cortex; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HC, hippocampus; PA

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

AMPK mediates a pro-survival autophagy downstream of PARP-1 activation in response to DNA alkylating agents

Keywords: Autophagy; AMPK; Alkylating agent; DNA damage; PARP-1; Necrosis

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

PARP-1 and gene regulation: Progress and puzzles

Keywords: PARP-1; ARTD1; Chromatin; Gene expression; Transcription; Regulation; Activity; ADP-ribosylation; Poly(ADP-ribose); Posttranslational modification

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

Methylation of PARP-1 promoter involved in the regulation of nano-SiO2-induced decrease of PARP-1 mRNA expression

Keywords: Nano silicon dioxide; Nano-SiO2; DNA methylation; PARP-1

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

A derivative of the CRMP2 binding compound lanthionine ketimine provides neuroprotection in a mouse model of cerebral ischemia

Keywords: CRMP2; collapsin response mediator protein 2; H2O2; hydrogen peroxide; LKE; lanthionine ketimine-ethyl ester; MCAO; middle cerebral artery occlusion; NDS; neurologic deficit score; t-BuOOH; tertiary butylhydroperoxide; TFM; terpene free material; p-MCAO;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

NGF promotes long-term memory formation by activating poly(ADP-ribose)polymerase-1

Keywords: NGF; polyADP-ribose-polymerase-1; Memory; Synaptic plasticity; NGF; Nerve growth factor; PARP-1; Poly(ADP-ribose)polymerase-1; 3-AB; 3-Aminobenzamide; AD; Alzheimer's disease; PKA; Protein Kinase A; CREB; cAMP-Responsive Element-Binding Protein; TrkA; tro

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Lipopolysaccharide activates ERK–PARP-1–RelA pathway and promotes nuclear factor–κB transcription in murine macrophages

Keywords: PARP-1; NF-κB; LPS; ERK; Inflammation

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Mast cell apoptosis induced by siramesine, a sigma-2 receptor agonist

Keywords: MC; mast cell; mMCP; mouse mast cell protease; BMMC; bone marrow-derived mast cell; PCMC; peritoneal cell-derived mast cell; PARP-1; Poly(ADP-ribose) polymerase-1; AO; acridine orange; WT; wild type; AnnV; Annexin V; CPA3; carboxypeptidase A3; Ig; immunog

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis and SAR optimization of quinazolin-4(3H)-ones as poly(ADP-ribose)polymerase-1 inhibitors

Keywords: Quinazolinone; PARP-1; BRCA1; p53; Docking3-AB, 3-aminobenzamide; BER, base excision repair; BRCA, breast cancer susceptibility gene; ClogP, calculated logarithm of partition coefficient; DMSO, dimethyl sulfoxide; EDTA, ethylenediamine tetraacetic acid; M

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Regulation and protection of mitochondrial physiology by sirtuins

Keywords: Acetyl-CoA; acetyl-coenzyme A; AceCS2; acetyl-coenzyme A synthethase 2; ACC; Acetyl-CoA carboxylase; ADP; adenosine diphosphate; AIF; apoptosis-inducing factor; AMPK; 5′ adenosine monophosphate-activated protein kinase; ANT; adenine nucleotide transloca

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Hypersensitivity of A8344G MERRF mutated cybrid cells to staurosporine-induced cell death is mediated by calcium-dependent activation of calpains

Keywords: CPEO; Chronic Progressive External Ophthalmoplegia; KSS; Kearns-Sayre Syndrome; LHON; Leber's Hereditary Optic Neuropathy; MELAS; Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-like episodes; MERRF; Myoclonic Epilepsy with Ragged Red Fibers;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

RECQ1 plays a distinct role in cellular response to oxidative DNA damage

Keywords: SSB; single strand breaks; DSB; double strand breaks; BER; base excision repair; HR; homologous recombination; PAR; poly(ADP)ribose; PARP; poly(ADP)ribose polymerase; RecQ; Helicase; PARP-1; Oxidative DNA damage; DNA repair;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells

Keywords: BER; base excision repair; BRCA1; breast cancer type 1 susceptibility protein; HMC; Hoffman modulation contrast; HR; homologous recombination; NER; nucleotide excision repair; NHEJ; non-homologous end joining; MMP; mitochondrial membrane potential; PARP-1

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Impact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme

Keywords: Glioblastoma multiforme; Postoperative radiotherapy; Survival; PARP-1; DNA-PK;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

PARP-1 regulates the expression of caspase-11

Keywords: PARP-1; Caspase-11; LPS; NF-κB; Inflammation;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Competition between PARP-1 and Ku70 control the decision between high-fidelity and mutagenic DNA repair

Keywords: PARP-1; DNA–PK; DNA repair; Gene conversion

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Poly(ADP-ribose) polymerase-1 protects from oxidative stress induced endothelial dysfunction

Keywords: PARP-1; Oxidative stress; Endothelial dysfunction;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Identification of PARP-1 as one of the transcription factors binding to the repressor element in the promoter region of COX-2

Keywords: Cyclooxygenase-2; Gene expression; Transcription; PARP-1

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Cyclic-stretch induces the apoptosis of myoblast by activation of Caspase-3 protease in a magnitude-dependent manner

Keywords: Cyclic stretch; Apoptosis; Myoblast; Caspase-3; PARP-1

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Glucagon-like peptide 1 protects microvascular endothelial cells by inactivating the PARP-1/iNOS/NO pathway

Keywords: Glucagon-like peptide-1 (GLP-1); Islet microvascular endothelial cells; Oxidized low-density lipoprotein; PARP-1; iNOS; GLP-1 receptor;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

iNOS induction and PARP-1 activation in human atherosclerotic lesions: an immunohistochemical and ultrastructural approach

Keywords: Atherosclerosis; iNOS; PARP-1; Oxidative stress; Mitochondrial damage

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Minocycline reduces plaque size in diet induced atherosclerosis via p27Kip1

Keywords: GOT; glutamate-oxalacetate transaminase (AST); GPT; glutamate pyruvate transaminase (ALT); HASMC; human aortic smooth muscle cell; HFD; high fat diet; MMP; matrix metalloproteinase; PAR; poly ADP-ribosylation; PARP-1; poly [ADP-ribose] polymerase 1; VSMC;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Topoisomerase IIβ associates with Ku70 and PARP-1 during double strand break repair of DNA in neurons

Keywords: PARP-1; Ku70; Topoisomerase IIβ; Neurons; DSB repair; Peroxide; NHEJ

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Oxidative stress initiates DNA damager MNNG-induced poly(ADP-ribose)polymerase-1-dependent parthanatos cell death

Keywords: DNA damage; ROS; PARP-1; RIP1; JNK; Parthanatos

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Neuroprotective potential of erythropoietin and its derivative carbamylated erythropoietin in periventricular leukomalacia

Keywords: Erythropoietin; Carbamylated erythropoietin; White matter injury; Oligodendrocyte; Microglia; PARP-1; Hypoxia–ischemia; Lipopolysaccharide; Periventricular leukomalacia

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Molecular adaptations of apoptotic pathways and signaling partners in the cerebral cortex of human cocaine addicts and cocaine-treated rats

Keywords: cocaine addiction; postmortem human brain; rat brain; Fas-FADD complex; PARP-1 cleavage; apoptotic signaling; AIF; apoptosis-inducing factor; Akt/PKB; v-akt murine thymoma viral oncogene homologue/protein kinase B; Bax; Bcl-2 associated X protein; Bcl-2

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه

Selective targeting of breast cancer cells through ROS-mediated mechanisms potentiates the lethality of paclitaxel by a novel diterpene, gelomulide K

Keywords: ROS; reactive oxygen species; PEG-SOD; polyethylene glycol-superoxide dismutase; PEG-CAT; polyethylene glycol-catalase; NAC; N-acetyl-l-cysteine; hGST; human glutathione S-transferase; tSBO; trans-stilbene oxide; AIF; apoptosis-inducing factor; PARP-1

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2011 سفارش ترجمه

Methylation of PARP-1 promoter involved in the regulation of benzene-induced decrease of PARP-1 mRNA expression

Keywords: 5-Aza-2′-deoxycytidine; Trichostatin A; Benzene; PARP-1

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Age-dependent posttranslational modifications of voltage-dependent anion channel 1

Keywords: AD; Alzheimer's disease; BBE; bovine brain extract; EGM; endothelial growth medium; ESC; embryonic stem cells; FBS; fetal bovine serum; hEGF; human endothelial growth factor; HRP; horse radish peroxidise; Hsp; heat shock protein; HUVEC; human umbilical

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1)

Keywords: Pyrrolo[1,2-a]pyrazin-1(2H)-one; Poly(ADP-ribose) polymerase; PARP-1; Oncology; Selectivity; BRCA1

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Epigenetic mediated transcriptional activation of PARP-1 participates in silica-associated malignant transformation of human bronchial epithelial cells

Keywords: Silica; PARP-1; 16 HBE; Malignant transformation; Epigenetic

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity

Keywords: SIRT1; Oxidants; NAD+; PARP-1; Cigarette smoke

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: Implication in pathogenesis of COPD

Keywords: SIRT1; PARP-1; Resveratrol; Cigarette smoke; Autophagy

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Role of JNK activation in pancreatic β-cell death by streptozotocin

Keywords: JNK; Streptozotocin; PARP-1; MKP; ROS

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

The expression and distribution of deoxyribonucleic acid repair and apoptosis markers in testicular germ cells of infertile varicocele patients resembles that of old fertile men

Keywords: Aging; DNA repair; varicocele; apoptosis; germ cells; PARP-1; caspase

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks

Keywords: PARP-1; PARP inhibitor; Methyl methanesulfonate; Cell cycle; Double-strand breaks; γ-H2A.X

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه