Iduna protects HT22 cells from hydrogen peroxide-induced oxidative stress through interfering poly(ADP-ribose) polymerase-1-induced cell death (parthanatos)

► Oxidative stress directly induced parthanatos. ► Iduna protected HT22 cells from oxidative stress. ► Protective effects of Iduna is dependent on inhibition of parthanatos. ► Ubiquitin-proteasome system contributed to the protective effects of Iduna.