PARP-1 regulates the expression of caspase-11

► Knockdown of PARP-1 suppresses the LPS-induced expression of caspase-11. ► Knockdown of PARP-1 suppresses the caspase-11 promoter activity following LPS stimulation. ► PARP-1 is recruited to the caspase-11 promoter region containing NF-κB-binding sites following LPS stimulation. ► PARP-1 inhibitors cannot suppress the caspase-11 induction. ► PARP-1 does not suppress IFN-γ-induced expression of caspase-11.