p21CDKN1A participates in base excision repair by regulating the activity of poly(ADP-ribose) polymerase-1
Keywords: p21CDKN1A; PARP-1; Base excision repair; PCNA; MNNG
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Ex vivo supplementation with nicotinic acid enhances cellular poly(ADP-ribosyl)ation and improves cell viability in human peripheral blood mononuclear cells
Keywords: Poly(ADP-ribosyl)ation; PARP-1; NAD+; Necrosis; PBMC
Poly(ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications
Keywords: PARP-1; Apoptosis; Necrosis; DNA repair; PARP inhibitors;
Ethanol-induced downregulation of the angiotensin AT2 receptor in murine fibroblasts is mediated by PARP-1
Keywords: Alcohol; Ethanol; Renin–angiotensin system; Angiotensin II AT2 receptor; Gene regulation; PARP-1
Roles of Werner syndrome protein in protection of genome integrity
Keywords: γ-H2AX; phosphorylated histone H2AX; 4-NQO; 4-nitroquinoline 1-oxide; 5-OHdC; 5-hydroxycytidine; 5-OHU; 5-hydroxyuracil; 8-oxodA; 8-oxoadenine; 8-oxodG; 8-oxoguanine; ALT; alternative lengthening of telomeres; APE1; apurinic/apyrimidinic endonuclease 1;
Microglial Activation in Stroke: Therapeutic Targets
Keywords: NF-κB; AP-1; PARP-1; minocycline; inflammation; ischemia; TREM2;
Extensive glial apoptosis develops early after hypoxic-dysmetabolic insult to the neonatal rat spinal cord in vitro
Keywords: astrocyte; oligodendrocyte; locomotion; ischemia; spinal injury; CV; coefficient of period variation; DAPI; 4â²,6-diamidino-2-phenylindole; DSB; double-stranded breaks; GFAP; glial fibrillary acidic protein; γH2AX; phosphorylated (Ser 139) histon H2A.X;
Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1
Keywords: PARP-1; Mouse models; Aging; Age-related diseases; Cancer; DNA repair; FADU; Inflammation; Grading of histopathology
Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors
Keywords: PARP-1; Isoquinolinone; Cytotoxic potentiation
Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)
Keywords: PARP-1; Poly(ADP-ribose)polymerase; Quinoxalinone; Nuclear enzyme; DNA repair; Programmed cell death; Nicotinamide;
Regulation of FOXO1-mediated transcription and cell proliferation by PARP-1
Keywords: FOXO1; PARP-1; Poly(ADP-ribosyl)ation; Cell proliferation
Backup pathways of NHEJ in cells of higher eukaryotes: Cell cycle dependence
Keywords: Ionizing radiation; DNA repair; Non-homologous end joining (NHEJ); Homologous recombination; Double-Strand Breaks; DNA-PK; DNA ligase III; Histone H1; PARP-1
Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS
Keywords: Alkylating agent; N7-methylguanine; AP sites; Base excision repair; Single strand breaks; PARP-1;
PKCη confers protection against apoptosis by inhibiting the pro-apoptotic JNK activity in MCF-7 cells
Keywords: PKC; protein kinase C; JNK; c-Jun N-terminal kinase; PARP-1; Poly ADP-ribose polymerase-1; MAPK; mitogen-activated protein kinase; CPT; Camptothecin; Tet; Tetracycline; PKCη; Apoptosis; UVC irradiation; Camptothecin; Cytochrome c; Caspases; JNK activity;
Calcium dysregulation induces apoptosis-inducing factor release: Cross-talk between PARP-1- and calpain- signaling pathways
Keywords: NMDA toxicity; Calpain; PARP-1; Apoptosis-inducing factor; Ischemia; Mitochondria; Calcium homeostasis
Role of Parp-1 in suppressing spontaneous deletion mutation in the liver and brain of mice at adolescence and advanced age
Keywords: Parp-1; Mutation; Deletion; gpt delta; Aging
Deoxyribonucleic acid repair and apoptosis in testicular germ cells of aging fertile men: the role of the poly(adenosine diphosphate-ribosyl)ation pathway
Keywords: Aging; DNA repair; apoptosis; germ cells; PARP-1; caspase;
PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM
Keywords: PARP-1; PARP inhibitor; Methyl methanesulfonate; ATM; Chk2; Cell cycle;
Regulation of poly(ADP-ribose) polymerase-1 functions by leukocyte elastase inhibitor/LEI-derived DNase II during caspase-independent apoptosis
Keywords: AIF; apoptosis-inducing factor; BHK; Baby Hamster Kidney; CAD; caspase-activated DNase; LEI; leukocyte elastase inhibitor; L-DNase II; LEI-derived DNase II; MEF; mouse embryonic fibroblasts; MNNG; N-methyl-Nâ²-nitro-N-nitrosoguanidine; PAR; poly-ADP-ribo
Functional dissection of an IFN-α/β receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection
Keywords: SNPs; single nucleotide polymorphisms; IFNAR1; IFN-α/β receptor 1; HMGB1; High mobility group B protein 1; PARP-1; poly(ADP-ribose) transferase-1; EMSAs; electrophoretic mobility shift assays; ChIP; chromatin immunoprecipitation; 3-AB; 3-Aminobenzamide;
Poly(ADP-ribose) polymerase-1 (PARP-1) transcriptionally regulates angiotensin AT2 receptor (AT2R) and AT2R binding protein (ATBP) genes
Keywords: RAS; renin-angiotensin system; AT1R; angiotensin AT1 receptor; AT2R; angiotensin AT2 receptor; PARP-1; poly(ADP-ribose) polymerase-1; SHP-1; SH2 domain-containing phosphatase 1; PLZF; promyelocytic zinc finger protein; ATBP; AT2R binding protein; ATIP;
Treatment Options for Breast Cancer Resistant to Anthracycline and Taxane
Keywords: ABC; ATP-binding cassette; BCRP; breast cancer resistance protein; CI; confidence interval; EGFR; epidermal growth factor receptor; FDA; Food and Drug Administration; HER2; human epidermal growth factor receptor 2; IRR; independent radiology review; MBC;
Novel alkoxybenzamide inhibitors of poly(ADP-ribose) polymerase
Keywords: Poly(ADP-ribose) polymerase-1; PARP-1; PARP-2
Effect of zinc on cellular poly(ADP-ribosyl)ation capacity
Keywords: PARP-1; Poly(ADP-ribosyl)ation capacity; Zinc supplementation; Aging
Identification of poly(ADP-ribose) polymerase-1 as the OXPHOS-generated ATP sensor of nuclei of animal cells
Keywords: Adenylate kinase; PARP-1; OXPHOS; Topo I; mRNA
Benzo[a]pyrene-induced necrosis in the HepG2 cells via PARP-1 activation and NAD+ depletion
Keywords: Cell death; PARP-1; NAD+; Necrosis; Benzo[a]pyrene; HepG2
p53-, SIRT1-, and PARP-1-independent downregulation of p21WAF1 expression in nicotinamide-treated cells
Keywords: Nicotinamide; NAD+; SIRT1; p21WAF1; Sp1; p53; PARP-1
Poly(ADPR)polymerase inhibition and apoptosis induction in cDDP-treated human carcinoma cell lines
Keywords: Cisplatin (cDDP); PARP-1; PJ34 inhibitor; p53; Carcinoma cells
Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks
Keywords: BER; base excision repair; PARP-1; poly(ADP-ribose) polymerase-1; SSB; single strand break; DSB; double strand break; Pol β; DNA polymerase β; XRCC1; X-ray cross-complementing protein-1; SiRNA; small interfering RNA; PARP-1; DNA repair; Base excision re
Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity
Keywords: As; sodium arsenite; UVR; ultraviolet radiation; PARP-1; poly(ADP-ribose) polymerase-1; SSB; single-strand break; DSB; double-strand break; ROS; reactive oxygen species; 8-OHdG; 8-hydroxyl-2'-deoxyguanine; BER; base excision repair; NER; nucleotide exci
Low-dose hypersensitive γH2AX response and infrequent apoptosis in epidermis from radiotherapy patients
Keywords: γH2AX; Hypersensitivity; Apoptosis; Epidermis; Normal tissue; Parp-1; DNA damage; DNA repair; Double strand breaks; DSB; Digital image analysis; Foci
Poly ADP-ribose polymerase-1: An international molecule of mystery
Keywords: PARP-1; DNA repair; Base excision repair; Single-strand break; Neurological disorders
Novel poly(ADP-ribose) polymerase-1 inhibitors
Keywords: PARP-1; pyrrolocarbazole; thiazole
Multiple roles for poly(ADP-ribose)polymerase-1 in neurological disease
Keywords: PARP-1; Neuronal death; Inflammation; DNA repair; Neuroprotection
Haploinsufficiency of poly(ADP-ribose) polymerase-1-mediated poly(ADP-ribosyl)ation for centrosome duplication
Keywords: Centrosome; Poly(ADP-ribosyl)ation; PARP-1; Haploinsufficiency;
WRN counteracts the NHEJ pathway upon camptothecin exposure
Keywords: RecQ; WRN; Ku70; DNA-PKcs; DT40; BLM; CPT; TopI; Etoposide; PARP-1
The role of poly(ADP-ribose) polymerase-1 in CNS disease
Keywords: DNA; transcription; inflammation; cell death; oxidative stress; AIF; apoptosis-inducing factor; DPQ 3; 4-dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone; EAE; experimental allergic encephalomyelitis; GPI 6150; 1,11b-dihydro-[2H]benzopyrano[4,3,2-
Decreased PARP-1 levels accelerate embryonic lethality but attenuate neuronal apoptosis in DNA polymerase β-deficient mice
Keywords: DNA polymerase β; PARP-1; Knockout mouse; Development; Neuronal apoptosis
Pharmacological inhibition of PARP-1 reduces α-synuclein- and MPP+-induced cytotoxicity in Parkinson’s disease in vitro models
Keywords: Parkinson’s disease; PARP-1; Inhibitors; Neuroprotection; α-Synuclein; MPP+; Neurodegeneration
The proteasome and its role in nuclear protein maintenance
Keywords: Protein degradation; Proteasome; Nucleus; PARP-1; Oxidative stress; Aging
Poly(ADPR)polymerase-1 signalling of the DNA damage induced by DNA topoisomerase I poison in D54p53wt and U251p53mut glioblastoma cell lines
Keywords: Glioblastoma cells; Topotecan; NU1025; PARP-1; TOPO I; p53; p21
ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity
Keywords: PARP-1; PARP inhibitor; Base excision repair; Methyl methanesulfonate; Cell cycle; Cell signaling; Chk1; ATR; γH2AX
Analysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients
Keywords: Breast cancer; PARP-1; Genetic variant; Haplotype-tagging SNP
Retrodifferentiation and rejuvenation of senescent monocytic cells requires PARP-1
Keywords: Leukemic cells; Retrodifferentiation; Tumor development; Growth control; Aging; Rejuvenation; PARP-1
Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells
Keywords: Arsenic; Methylated metabolites; Poly(ADP-ribosyl)ation; PARP-1; DNA repair
Functional Interaction of DNA Topoisomerase IIα With the β-Catenin and T-Cell Factor-4 Complex
Keywords: APC; adenomatous polyposis coli; dsDNA; double-strand DNA; HEK; human embryonic kidney; kDNA; kinetoplast DNA; LEF; lymphoid enhancer factor; PARP-1; poly(ADP-ribose) polymerase-1; siRNA; small interfering RNA; TCF-4; T cell factor-4; Topo II; DNA topoiso
Prolonged poly(ADP-ribose) polymerase-1 activity regulates JP-8-induced sustained cytokine expression in alveolar macrophages
Keywords: JP-8 jet fuel; Oxidative stress; Inflammation; Alveolar macrophages; NF-κB; PARP-1; Free radicals
Overactivation of poly(adenosine phosphate-ribose) polymerase 1 and molecular events in neuronal injury after deep hypothermic circulatory arrest: Study in a rabbit model
Keywords: 19; 21; 25; ADP; adenosine diphosphate; ATP; adenosine triphosphate; CPB; cardiopulmonary bypass; DHCA; deep hypothermic circulatory arrest; NAD+; nicotinamide adenine dinucleotide; PAR; Poly(ADP-ribose); PARP-1; poly(adenosine diphosphate-ribose) polym
Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency
Keywords: Base excision repair; DNA polymerase β; XRCC1; PARP-1; PARP inhibitor
Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair
Keywords: amyotrophic lateral sclerosis; ataxia-telangiectasia-like disorder; Werner syndrome; xeroderma pigmentosum; nitric oxide synthase; superoxide dismutase; AfXPB; Archaeoglobus fulgidus XPB; AH; autoinhibitory helix; ALS; amyotrophic lateral sclerosis; ATL