کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1364979 | 981550 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel alkoxybenzamide inhibitors of poly(ADP-ribose) polymerase
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We have previously described poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors based on a substituted benzyl-phthalazinone scaffold. As an alternative chemical template, a novel series of alkoxybenzamides were developed with restricted conformation through intramolecular hydrogen bond formation; the compounds exhibit low nM enzyme and cellular activity as PARP-1 inhibitors.
A novel series of alkoxybenzamides have been developed with restricted conformation through intramolecular hydrogen bond formation. The compounds exhibit low nM enzyme and cellular activity as poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 14, 15 July 2008, Pages 3942–3945
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 14, 15 July 2008, Pages 3942–3945
نویسندگان
Keith A. Menear, Claire Adcock, Francisco Cuenca Alonso, Kristel Blackburn, Louise Copsey, Jan Drzewiecki, Alexandra Fundo, Armelle Le Gall, Sylvie Gomez, Hashim Javaid, Carlos Fenandez Lence, Niall M.B. Martin, Chris Mydlowski, Graeme C.M. Smith,