کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6263622 | 1613904 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cellular NAD depletion and decline of SIRT1 activity play critical roles in PARP-1-mediated acute epileptic neuronal death in vitro
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کلمات کلیدی
Sirt1PARP-1Cytochrome oxidase subunit IV3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinonedpqMPTCOXIVPoly(ADP-ribose)polymerase-1HNCWCCAIF - آیفونmitochondrial permeability transition - انتقال نفوذپذیری میتوکندریEpilepsy - بیماری صرعTerminal deoxynucleotidyl transferase-mediated dUTP nick end labeling - ترمینال deoxynucleotidyl transferase-mediated dUTP نام نهایی پایان نامهPar - توسطTUNEL - تونلacquired epilepsy - صرع به دست آوردapoptosis-inducing factor - عامل القاء آپوپتوزNeuronal death - مرگ نورونNAD - نادانNAD, nicotinamide adenine dinucleotide - نیکوتینامید آدنین دینوکلئوتیدPoly(ADP-ribose) - پلی (ADP-ribose)Poly(ADP-ribose) polymerase-1 - پلی (ADP-ribose) پلیمراز-1
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Intense poly(ADP-ribose) polymerase-1 (PARP-1) activation was implicated as a major cause of caspase-independent cell death in the hippocampal neuronal culture (HNC) model of acute acquired epilepsy (AE). The molecular mechanisms are quite complicated. The linkage among neuronal death, cellular nicotinamide adenine dinucleotide (NAD) levels, apoptosis-inducing factor (AIF) translocation, SIRT1 expression and activity were investigated here. The results showed that PARP-1 over-activation caused by Mg2+-free stimuli led to cellular NAD depletion which could block AIF translocation from mitochondria to nucleus and attenuate neuronal death. Also, SIRT1 deacetylase activity was reduced by Mg2+-free treatment, accompanied by elevated ratio of neuronal death, which could be rescued by NAD repletion. These data demonstrated that cellular NAD depletion and decline of SIRT1 activity play critical roles in PARP-1-mediated epileptic neuronal death in the HNC model of acute AE.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1535, 16 October 2013, Pages 14-23
Journal: Brain Research - Volume 1535, 16 October 2013, Pages 14-23
نویسندگان
Shengjun Wang, Xue Yang, Youting Lin, Xiaoxue Qiu, Hui Li, Xiuhe Zhao, Lili Cao, Xuewu Liu, Yuejiu Pang, Xuping Wang, Zhaofu Chi,