دانلود مقالات ISI درباره بازرسی کیناز 1 + ترجمه فارسی

علل شیوه زندگی ناباروری مردانه

Lifestyle causes of male infertility

Keywords: بازرسی کیناز 1; AAS; anabolic-androgenic steroids; APA; advanced paternal age; ASIH; anabolic steroid-induced hypogonadism; ART; assisted reproductive technology; BMI; body mass index; Chk1; checkpoint kinase 1; ECS; endogenous cannabinoid system; GnIH; gonadotropin-in

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

سیلیکا - عنصر ژئوشیمیایی ردیابی با پدیده نفوذپذیری در حال ظهور است

Silica - A trace geogenic element with emerging nephrotoxic potential

Keywords: بازرسی کیناز 1; Apaf-1; Apoptotic protease-activating factor-1; A498; Renal proximal tubular carcinoma; BCA; Bicinchoninic acid; Bax; Bcl-2 associated X protein; Bcl-2; B-cell lymphoma 2; BSA; Bovine Serum Albumin; Cdc25; Cell-division control protein 25(Dual-Specificity

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2018 سفارش ترجمه

ترکیب شیمیایی و درمان مولکولی هدفمند

Integrating chemoradiation and molecularly targeted therapy

Keywords: بازرسی کیناز 1; SBRT; Stereotactic body radiation therapy; 5-FU; 5-fluorouracil; FdUMP; Fluoro-deoxyuridine-monophosphate; FdUTP; Fluoro-deoxyuridine-triphosphate; FUTP; Fluorouridine triphosphate; CHK1; Checkpoint kinase 1; PARP; Poly(ADP-ribose) polymerase; EGFR; Epide

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

پس زدن به عنوان نقطه پایانی بیولوژیک پس از هدف گذاری فارماکولوژیک گیرنده های تیروزین کیناز در سرطان

Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer

Keywords: بازرسی کیناز 1; ATIR; anti-tumor immune response; ATM; ataxia telangiectasia mutated; CDK; cyclin-dependent kinase; CGH; comparative genomic hybridization; CHK1; checkpoint kinase 1; CHK2; checkpoint kinase 2; DDAs; DNA-damaging agents; DDR; DNA damage response; DSBs; do

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

پایداری ژنوم محصولات برنامه ریزی شده سلول های بنیادی

Genome stability of programmed stem cell products

Keywords: بازرسی کیناز 1; ATM; ataxia-telangiectasia mutated; BCL2L1; BCL2 like 1; CGH; comparative genomic hybridization; CHK; checkpoint kinase 1; CIN; chromosomal instability; CNVs; copy number variations; DNMT3B; DNA methyltransferase 3B; DPPA3; developmental pluripotency asso

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of NMU as a potential gene conferring alectinib resistance in non-small cell lung cancer based on bioinformatics analyses

Keywords: بازرسی کیناز 1; NSCLC; non-small cell lung cancer; ALK; anaplastic lymphoma kinase; GEO; gene expression omnibus; DEGs; differentially expressed genes; DAVID; database for annotation, visualization and integrated discovery; GO; gene ontology; KEGG; kyoto encyclopedia of

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2018 سفارش ترجمه

Chk1 inhibitors overcome imatinib resistance in chronic myeloid leukemia cells

Keywords: بازرسی کیناز 1; Chronic myelogenous leukemia; Checkpoint kinase 1; Bcr-Abl; Drug resistance;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

KRAS-Mutant non-small cell lung cancer: From biology to therapy

Keywords: بازرسی کیناز 1; BATTLE; Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination; BET; bromodomains and extra-terminal domain; CDK; cyclin-dependent kinase; Chk1; checkpoint kinase 1; CI; confidence interval; CUSTOM; Molecular Profiling and Targete

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Melanoma antigen-D2 controls cell cycle progression and modulates the DNA damage response

Keywords: بازرسی کیناز 1; APC/C; anaphase-promoting complex or cyclosome; ATM; ataxia-telangiectasia mutated protein; ATR; ataxia-telangiectasia- and rad3-related protein; CDC20; cell division cycle protein 20; CDK; cyclin-dependent kinase; CHK1; checkpoint kinase 1; CHK2; checkpo

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

CCRK is a novel signalling hub exploitable in cancer immunotherapy

Keywords: بازرسی کیناز 1; 9G8; serine and arginine rich splicing factor 7; AKT; AKT serine/threonine kinase; AR; androgen receptor; ARE; androgen response element; ARG1; arginase 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and rad3-related protein; BMDC; mous

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2018 سفارش ترجمه

Harmines inhibit cancer cell growth through coordinated activation of apoptosis and inhibition of autophagy

Keywords: بازرسی کیناز 1; Harmine; Anticancer effect; DNA damage response; Autophagy; Apoptosis; ATR; ATM and Rad3-related; CPT; camptothecin; cck-8; cell count kit-8; Chk1; checkpoint kinase 1; DOX; doxorubicin; PARP; poly (ADP-ribose) polymerase; PI; propidium iodide; UPLC-Q-TOF

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2018 سفارش ترجمه

DNA repair mechanisms in response to genotoxicity of warfare agent sulfur mustard

Keywords: بازرسی کیناز 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and rad3 related; BER; base excision repair; Cdc25; cell division cycle 25; CDKs; cyclin-dependent kinases; CEES; 2-chloroethyl ethyl sulphide; ChK1; checkpoint kinase 1; Chk2; checkpoint kina

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2018 سفارش ترجمه

Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells

Keywords: بازرسی کیناز 1; ABTS; 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid); CAT; catalase; Chk1; checkpoint kinase 1; H2DCFDA; 2′,7′-dichlorodihydrofluorescein diacetate; HMEC-1; human microvascular endothelial cells; HMTs; histone methyltransferases; TAC; total

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

Camptosorus sibiricus rupr aqueous extract prevents lung tumorigenesis via dual effects against ROS and DNA damage

Keywords: بازرسی کیناز 1; CSR; Camptosorus sibiricus Rupr; B[a]P; benzo(a)pyrene; ROS; reactive oxygen species; UPLC-DAD-QTOF; Ultra performance liquid chromatography-Diode array detector-QTOF; HPLC DMEM; High Performance Liquid Chromatography Dulbecco's modified Eagle's medium; M

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

Keywords: بازرسی کیناز 1; Autophagy; Combination therapy; Erlotinib; Vps34; High-content screening; AKT; Protein kinase B; ATG7; Autophagy-related protein 7; BafA1; Bafilomycin A1; Chk1; Checkpoint kinase 1; CQ; Chloroquine; FGFR; Fibroblast growth factor receptor; GFP; Green fluo

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Cross-species comparison of the gut: Differential gene expression sheds light on biological differences in closely related tenebrionids

Keywords: بازرسی کیناز 1; Tenebrionid gut; Gut transcriptome; Tribolium castaneum; Tenebrio molitor; BP; Biological Process; CC; Cellular Component; CHK1; checkpoint kinase 1; HEX3; hexamerin 3; INDY; I'm not dead yet; GO; gene ontology; MF; molecular function; PPK28; pickpocket

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2018 سفارش ترجمه

BTG3, a candidate tumor suppressor, promotes methylation of checkpoint kinase CHK1

Keywords: بازرسی کیناز 1; BTG3; B-cell translocation gene 3; CHK-1; Checkpoint kinase 1; SDS; sodium dodecyl sulfate; PAGE; PA-gel electrophoresis; DTT; dithiothreitol; BTG3 overexpression; CHK1 methylation; Immunoblotting; Immunoprecipitation;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

A randomized, phase 2 evaluation of the CHK1 inhibitor, LY2603618, administered in combination with pemetrexed and cisplatin in patients with advanced nonsquamous non‐small cell lung cancer

Keywords: بازرسی کیناز 1; CHK1; selective inhibitor of checkpoint kinase 1; LY + Pem + Cis; LY2603618 + pemetrexed + cisplatin; Pem + Cis; pemetrexed + cisplatin; Checkpoint kinase 1; Cisplatin; Pemetrexed; LY2603618; Non-small cell lung cancer;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

APCCdh1 controls cell cycle entry during liver regeneration

Keywords: بازرسی کیناز 1; APC/C; anaphase-promoting complex/cyclosome; SCF; Skp1/CUL1/F-box protein; PHx; partial hepatectomy; QRT-PCR; quantitative reverse transcription-PCR; Chk1; checkpoint kinase 1; Cdh1; Replication; Liver regeneration;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Molecular basis for the regulation of the circadian clock kinases CK1δ and CK1ε

Keywords: بازرسی کیناز 1; ATP; adenosine triphosphate; CK1; casein kinase 1; CK2; casein kinase 2; CTD; C-terminal domain; TTFL; transcriptional and translational feedback loop; GSK-3β; glycogen synthase kinase 3β; MEFs; mouse embryonic fibroblast cells; ConA; concanavalin A; LP

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

E2F6 protein levels modulate drug induced apoptosis in cardiomyocytes

Keywords: بازرسی کیناز 1; α-mhc; α-myosin heavy chain; β2-AR; beta-2-adrenergic receptor; Bax; Bcl2 associated protein X; Bcl2; B-cell lymphoma 2; Blm2; bloom syndrome 2 homolog; Bnip3; Bcl2 interacting protein 3; Chk1; checkpoint kinase 1; c-src; proto-oncogene tyrosine protei

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Reverting p53 activation after recovery of cellular stress to resume with cell cycle progression

Keywords: بازرسی کیناز 1; AMPK; AMP - activate kinase alpha 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related protein; CHK2; checkpoint kinase 2; CHK1; checkpoint kinase 1; CDK; cyclin-dependent kinase; CDKN2A; cyclin dependent kinase inhibitor 2A;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticlemiR-875-5p counteracts epithelial-to-mesenchymal transition and enhances radiation response in prostate cancer through repression of the EGFR-ZEB1 axis

Keywords: بازرسی کیناز 1; microRNAs; Prostate cancer; Radiosensitivity; EMT; EGFR; CHK1; Checkpoint kinase 1; EGFR; Epidermal growth factor receptor; EMT; Epithelial-to-mesenchymal transition; HR; Homologous recombination; LIN7C; Lin-7 homolog C; miRNA; microRNA; NHEJ; Non homolog

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells

Keywords: بازرسی کیناز 1; CDDP; cisplatin; Chk1; checkpoint kinase 1; Chk2; checkpoint kinase 2; γ-H2AX; phosphorylated histone H2AX at Ser 139; LA-12; (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV); PARP; poly (ADP-ribose) polymerase; PBS; phosphate-buffered

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

G2/M cell cycle arrest on HT-29 cancer cells and toxicity assessment of triphenylphosphanegold(I) carbonimidothioates, Ph3PAu[SC(OR) = NPh], R = Me, Et, and iPr, during zebrafish development

Keywords: بازرسی کیناز 1; Annexin V-FITC; Recombinant annexin V conjugated to fluorescein isothiocyanate; APAF-1; Apoptotic protease activating factor 1; ATR; Ataxia telangiectasia and Rad3-related; Bax; Apoptosis regulator; Bcl-2; B-cell lymphoma 2; BIRC-5; Baculoviral inhibitor

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

QSAR study of pyrazolo[1,5-a]pyrimidine derivative inhibitors of Chk1

Keywords: بازرسی کیناز 1; Checkpoint kinase 1; Quantitative structure–activity relationship; Particle swarm optimization; Support vector machine

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Mdc1 modulates the interaction between TopBP1 and the MRN complex during DNA damage checkpoint responses

Keywords: بازرسی کیناز 1; Mdc1; TopBP1; MRN complex; Nbs1; DNA damage checkpoint; DSB; double-stranded DNA break; Mdc1; mediator of DNA damage checkpoint protein 1; Chk1; checkpoint kinase 1; ATM; ataxia-telangiectasia mutated; ATR; ATM and Rad3-related; IR; ionizing radiation; si

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

PKC-alpha modulation by miR-483-3p in platinum-resistant ovarian carcinoma cells

Keywords: بازرسی کیناز 1; API5; apoptosis inhibitor 5; ARF1; ADP ribosylation factor 3; BCA; bicinchoninic acid; BBC3/PUMA; BCL2 binding component 3; BIRC5; baculoviral IAP (inhibitor of apoptosis) repeat containing 5; CDC25A; cell division cycle 25A; CDK4; cyclin-dependent kinase

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Research ArticleHepatitis B virus induces RNR-R2 expression via DNA damage response activation

Keywords: بازرسی کیناز 1; HBV; hepatitis B virus; dNTPs; deoxyribonucleotide triphosphates; Chk1; checkpoint kinase 1; RNR; ribonucleotide reductase; DDR; DNA damage response; PHH; primary human hepatocytes; SDS-PAGE; sodium dodecyl sulfate polyacrylamide gel electrophoresis; qRT-

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Research ArticleHepatitis C virus-mediated Aurora B kinase inhibition modulates inflammatory pathway and viral infectivity

Keywords: بازرسی کیناز 1; HCV; hepatitis C virus; HCC; hepatocellular carcinoma; AURKB; Aurora B kinase; PP2; protein phosphatase 2; Chk1; checkpoint kinase 1; NF-κB; nuclear factor-κB; COX-2; cyclooxygenase-2; Hepatitis C; Inflammation; NF-κB; COX-2; Histone modifications;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

ATR signaling cooperates with ATM in the mechanism of low dose hypersensitivity induced by carbon ion beam

Keywords: بازرسی کیناز 1; IR; ionizing radiation; LET; linear energy transfer; HRS; hyper-radiosensitivity; IRR; induced radioresistance; DSB; DNA double strand break; ATM; ataxia telangiectasia mutated homolog; ATR; ataxia telangiectasia and Rad3 related; DNA-PKcs; DNA-dependent

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Platinum-induced kidney damage: Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury

Keywords: بازرسی کیناز 1; ApG; adenine-guanine; ATM; Ataxia telangiectasia mutated; ATR; ATM and Rad3 related kinase; Bax; Bcl2-associated X protein; Bcl2; B-cell CLL/lymphoma 2; EdU; 5-ethynyl-2′-deoxyuridine; CarboPt; carboplatin; CENP-F; centromere protein F; Chk1; checkpoint

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

CHEK again: Revisiting the development of CHK1 inhibitors for cancer therapy

Keywords: بازرسی کیناز 1; CHK1; Checkpoint kinase 1; DNA replication; WEE1; DNA damage responseATM, ataxia-telangiectasia mutated; ATR, ATM and Rad3 related; CHK1, Checkpoint Kinase 1; CHK2, Checkpoint Kinase 2; CDKs, Cyclin-dependent kinases; DDK, DBF4/DRF1-dependent CDC7 kinase;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Opportunities for translation: Targeting DNA repair pathways in pancreatic cancer

Keywords: بازرسی کیناز 1; ATR; ATM-Rad3-related; BER; base excision repair; Chk1; checkpoint kinase 1; DDR; DNA damage response and repair; DNA-PKcs; DNA-PK catalytic subunit; DOT1L; DOT1-like; DSB; double strand break; FOLFIRINOX; folinic acid, 5-FU, irinotecan, oxaliplatin; 5-FU

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Applications of NMR screening techniques to the pharmaceutical target Checkpoint kinase 1

Keywords: بازرسی کیناز 1; AEBSF; 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride; Chk1; Checkpoint kinase 1; DIRECTION; Difference of Inversion REcovery rate with and without Target IrradiatiON; DSBs; double strand breaks; HEPES; 4-(2-HydroxyEthyl)-1-PiperazineEthaneSulfoni

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

A site-selective, irreversible inhibitor of the DNA replication auxiliary factor proliferating cell nuclear antigen (PCNA)

Keywords: بازرسی کیناز 1; APC; allophycocyanin; ATR; ataxia telangiectasia mutated and rad3-related; BCA; bicinchoninic acid; Chk1; checkpoint kinase 1; CSK buffer; cytoskeleton buffer; DBU; 1,8-diazabicyclo[5.4.0]undec-7-ene; DCM; dichloromethane; DIPEA; N,N-diisopropylethylamine

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway

Keywords: بازرسی کیناز 1; Kinase inhibitor; p53 Pathway activation; Casein kinase 1; Checkpoint kinase 1;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Checkpoint kinase 1 inhibitors for potentiating systemic anticancer therapy

Keywords: بازرسی کیناز 1; Cell cycle checkpoints; Checkpoint kinase 1; Checkpoint kinase 2; Chemopotentiation; DNA damage response

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors

Keywords: بازرسی کیناز 1; Triazolones; CHK1; Checkpoint kinase 1; In vivo activity

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Disruptive cell cycle regulation involving epigenetic downregulation of Cdkn2a (p16Ink4a) in early-stage liver tumor-promotion facilitating liver cell regeneration in rats

Keywords: بازرسی کیناز 1; BNF; β-naphthoflavone; Cdc2; cell division cycle 2; Cdc25c; cell division cycle 25 homolog C (S. pombe); Cdk; cyclin-dependent kinase; Chk1; checkpoint kinase 1; CKI; cyclin-dependent kinase inhibitor; DEN; N-diethylnitrosamine; FB; fenbendazole; γH2AX;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Transient knock down of checkpoint kinase 1 in hematopoietic progenitors is linked to bone marrow toxicity

Keywords: بازرسی کیناز 1; Checkpoint kinase 1; Bone marrow suppression; RNAi;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Characterization of novel Checkpoint kinase 1 inhibitors by in vitro assays and in human cancer cells treated with topoisomerase inhibitors

Keywords: بازرسی کیناز 1; Checkpoint kinase 1; Camptothecin; Mitosis; DNA damage; Checkpoint adaptation; Cell cycle;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis of selenophene derivatives as novel CHK1 inhibitors

Keywords: بازرسی کیناز 1; Checkpoint kinase 1; CHK1 inhibitor; Kinase; Selenophene; Indolin-2-one

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

HTLV-1 Tax: Linking transformation, DNA damage and apoptotic T-cell death

Keywords: بازرسی کیناز 1; AP-1; activator protein 1; APC; anaphase promoting complex; ATL; adult T-cell leukemia; ATM kinase; ataxia telangiectasia mutated kinase; BES; base excision repair; Chk1; checkpoint kinase 1; Chk2; checkpoint kinase 2; CREB; cyclic AMP response element-bi

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

An unusual DNA binding compound, S23906, induces mitotic catastrophe in cultured human cells

Keywords: بازرسی کیناز 1; CPT, camptothecin; CDDP, cisplatin; Cdk1, cyclin-dependent kinase 1; Chk1, checkpoint kinase 1Cytotoxic drug; Cyclin-dependent kinases; Cdk1; DNA damage response; Checkpoint kinase 1; Histone γ-H2AX; Checkpoint adaptation

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Synthesis and biological evaluation of 4′-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors

Keywords: بازرسی کیناز 1; Checkpoint kinase 1; Chk1 inhibitor; Kinase; DNA damage; DNA repair; Pyrazole; Antitumor; Cancer

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Discovery of 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles and 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridine-2′-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors

Keywords: بازرسی کیناز 1; Antitumor agent; Chk1 inhibitors; Checkpoint kinase 1; Pyrazole; Structure–activity relationship; DNA damage; Combination therapy

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Macrocyclic ureas as potent and selective Chk1 inhibitors: An improved synthesis, kinome profiling, structure–activity relationships, and preliminary pharmacokinetics

Keywords: بازرسی کیناز 1; Checkpoint kinase 1; Chk1; Ureas; Kinase inhibitors; Macrocycles; Ring-closure metathesis; DNA damage

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

The Drosophila melanogaster DmCK2β transcription unit encodes for functionally non-redundant protein isoforms

Keywords: بازرسی کیناز 1; a.e.; after eclosion; cDNA; DNA complementary to RNA; CHK1; checkpoint kinase 1; CHK2; checkpoint kinase 2; CK2; casein kinase 2; Dm; Drosophila melanogaster; ds; double-stranded; GT; gene trap; h; hour; HA; hemagglutinin; HEK; human embryonic kidney; mbu

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Geldanamycin-induced degradation of Chk1 is mediated by proteasome

Keywords: بازرسی کیناز 1; Checkpoint kinase 1; Glioblastoma; Geldanamycin; Ubiquitin; Proteasome;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه