Keywords: بازرسی کیناز 1; AAS; anabolic-androgenic steroids; APA; advanced paternal age; ASIH; anabolic steroid-induced hypogonadism; ART; assisted reproductive technology; BMI; body mass index; Chk1; checkpoint kinase 1; ECS; endogenous cannabinoid system; GnIH; gonadotropin-in
مقالات ISI بازرسی کیناز 1 (ترجمه نشده)
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Keywords: بازرسی کیناز 1; Apaf-1; Apoptotic protease-activating factor-1; A498; Renal proximal tubular carcinoma; BCA; Bicinchoninic acid; Bax; Bcl-2 associated X protein; Bcl-2; B-cell lymphoma 2; BSA; Bovine Serum Albumin; Cdc25; Cell-division control protein 25(Dual-Specificity
Keywords: بازرسی کیناز 1; SBRT; Stereotactic body radiation therapy; 5-FU; 5-fluorouracil; FdUMP; Fluoro-deoxyuridine-monophosphate; FdUTP; Fluoro-deoxyuridine-triphosphate; FUTP; Fluorouridine triphosphate; CHK1; Checkpoint kinase 1; PARP; Poly(ADP-ribose) polymerase; EGFR; Epide
Keywords: بازرسی کیناز 1; ATIR; anti-tumor immune response; ATM; ataxia telangiectasia mutated; CDK; cyclin-dependent kinase; CGH; comparative genomic hybridization; CHK1; checkpoint kinase 1; CHK2; checkpoint kinase 2; DDAs; DNA-damaging agents; DDR; DNA damage response; DSBs; do
Keywords: بازرسی کیناز 1; ATM; ataxia-telangiectasia mutated; BCL2L1; BCL2 like 1; CGH; comparative genomic hybridization; CHK; checkpoint kinase 1; CIN; chromosomal instability; CNVs; copy number variations; DNMT3B; DNA methyltransferase 3B; DPPA3; developmental pluripotency asso
Identification of NMU as a potential gene conferring alectinib resistance in non-small cell lung cancer based on bioinformatics analyses
Keywords: بازرسی کیناز 1; NSCLC; non-small cell lung cancer; ALK; anaplastic lymphoma kinase; GEO; gene expression omnibus; DEGs; differentially expressed genes; DAVID; database for annotation, visualization and integrated discovery; GO; gene ontology; KEGG; kyoto encyclopedia of
Chk1 inhibitors overcome imatinib resistance in chronic myeloid leukemia cells
Keywords: بازرسی کیناز 1; Chronic myelogenous leukemia; Checkpoint kinase 1; Bcr-Abl; Drug resistance;
KRAS-Mutant non-small cell lung cancer: From biology to therapy
Keywords: بازرسی کیناز 1; BATTLE; Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination; BET; bromodomains and extra-terminal domain; CDK; cyclin-dependent kinase; Chk1; checkpoint kinase 1; CI; confidence interval; CUSTOM; Molecular Profiling and Targete
Melanoma antigen-D2 controls cell cycle progression and modulates the DNA damage response
Keywords: بازرسی کیناز 1; APC/C; anaphase-promoting complex or cyclosome; ATM; ataxia-telangiectasia mutated protein; ATR; ataxia-telangiectasia- and rad3-related protein; CDC20; cell division cycle protein 20; CDK; cyclin-dependent kinase; CHK1; checkpoint kinase 1; CHK2; checkpo
CCRK is a novel signalling hub exploitable in cancer immunotherapy
Keywords: بازرسی کیناز 1; 9G8; serine and arginine rich splicing factor 7; AKT; AKT serine/threonine kinase; AR; androgen receptor; ARE; androgen response element; ARG1; arginase 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and rad3-related protein; BMDC; mous
Harmines inhibit cancer cell growth through coordinated activation of apoptosis and inhibition of autophagy
Keywords: بازرسی کیناز 1; Harmine; Anticancer effect; DNA damage response; Autophagy; Apoptosis; ATR; ATM and Rad3-related; CPT; camptothecin; cck-8; cell count kit-8; Chk1; checkpoint kinase 1; DOX; doxorubicin; PARP; poly (ADP-ribose) polymerase; PI; propidium iodide; UPLC-Q-TOF
DNA repair mechanisms in response to genotoxicity of warfare agent sulfur mustard
Keywords: بازرسی کیناز 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and rad3 related; BER; base excision repair; Cdc25; cell division cycle 25; CDKs; cyclin-dependent kinases; CEES; 2-chloroethyl ethyl sulphide; ChK1; checkpoint kinase 1; Chk2; checkpoint kina
Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells
Keywords: بازرسی کیناز 1; ABTS; 2,2â²-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid); CAT; catalase; Chk1; checkpoint kinase 1; H2DCFDA; 2â²,7â²-dichlorodihydrofluorescein diacetate; HMEC-1; human microvascular endothelial cells; HMTs; histone methyltransferases; TAC; total
Camptosorus sibiricus rupr aqueous extract prevents lung tumorigenesis via dual effects against ROS and DNA damage
Keywords: بازرسی کیناز 1; CSR; Camptosorus sibiricus Rupr; B[a]P; benzo(a)pyrene; ROS; reactive oxygen species; UPLC-DAD-QTOF; Ultra performance liquid chromatography-Diode array detector-QTOF; HPLC DMEM; High Performance Liquid Chromatography Dulbecco's modified Eagle's medium; M
Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib
Keywords: بازرسی کیناز 1; Autophagy; Combination therapy; Erlotinib; Vps34; High-content screening; AKT; Protein kinase B; ATG7; Autophagy-related protein 7; BafA1; Bafilomycin A1; Chk1; Checkpoint kinase 1; CQ; Chloroquine; FGFR; Fibroblast growth factor receptor; GFP; Green fluo
Cross-species comparison of the gut: Differential gene expression sheds light on biological differences in closely related tenebrionids
Keywords: بازرسی کیناز 1; Tenebrionid gut; Gut transcriptome; Tribolium castaneum; Tenebrio molitor; BP; Biological Process; CC; Cellular Component; CHK1; checkpoint kinase 1; HEX3; hexamerin 3; INDY; I'm not dead yet; GO; gene ontology; MF; molecular function; PPK28; pickpocket
BTG3, a candidate tumor suppressor, promotes methylation of checkpoint kinase CHK1
Keywords: بازرسی کیناز 1; BTG3; B-cell translocation gene 3; CHK-1; Checkpoint kinase 1; SDS; sodium dodecyl sulfate; PAGE; PA-gel electrophoresis; DTT; dithiothreitol; BTG3 overexpression; CHK1 methylation; Immunoblotting; Immunoprecipitation;
A randomized, phase 2 evaluation of the CHK1 inhibitor, LY2603618, administered in combination with pemetrexed and cisplatin in patients with advanced nonsquamous nonâsmall cell lung cancer
Keywords: بازرسی کیناز 1; CHK1; selective inhibitor of checkpoint kinase 1; LY + Pem + Cis; LY2603618 + pemetrexed + cisplatin; Pem + Cis; pemetrexed + cisplatin; Checkpoint kinase 1; Cisplatin; Pemetrexed; LY2603618; Non-small cell lung cancer;
APCCdh1 controls cell cycle entry during liver regeneration
Keywords: بازرسی کیناز 1; APC/C; anaphase-promoting complex/cyclosome; SCF; Skp1/CUL1/F-box protein; PHx; partial hepatectomy; QRT-PCR; quantitative reverse transcription-PCR; Chk1; checkpoint kinase 1; Cdh1; Replication; Liver regeneration;
Molecular basis for the regulation of the circadian clock kinases CK1δ and CK1ε
Keywords: بازرسی کیناز 1; ATP; adenosine triphosphate; CK1; casein kinase 1; CK2; casein kinase 2; CTD; C-terminal domain; TTFL; transcriptional and translational feedback loop; GSK-3β; glycogen synthase kinase 3β; MEFs; mouse embryonic fibroblast cells; ConA; concanavalin A; LP
E2F6 protein levels modulate drug induced apoptosis in cardiomyocytes
Keywords: بازرسی کیناز 1; α-mhc; α-myosin heavy chain; β2-AR; beta-2-adrenergic receptor; Bax; Bcl2 associated protein X; Bcl2; B-cell lymphoma 2; Blm2; bloom syndrome 2 homolog; Bnip3; Bcl2 interacting protein 3; Chk1; checkpoint kinase 1; c-src; proto-oncogene tyrosine protei
Reverting p53 activation after recovery of cellular stress to resume with cell cycle progression
Keywords: بازرسی کیناز 1; AMPK; AMP - activate kinase alpha 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related protein; CHK2; checkpoint kinase 2; CHK1; checkpoint kinase 1; CDK; cyclin-dependent kinase; CDKN2A; cyclin dependent kinase inhibitor 2A;
Original ArticlemiR-875-5p counteracts epithelial-to-mesenchymal transition and enhances radiation response in prostate cancer through repression of the EGFR-ZEB1 axis
Keywords: بازرسی کیناز 1; microRNAs; Prostate cancer; Radiosensitivity; EMT; EGFR; CHK1; Checkpoint kinase 1; EGFR; Epidermal growth factor receptor; EMT; Epithelial-to-mesenchymal transition; HR; Homologous recombination; LIN7C; Lin-7 homolog C; miRNA; microRNA; NHEJ; Non homolog
Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells
Keywords: بازرسی کیناز 1; CDDP; cisplatin; Chk1; checkpoint kinase 1; Chk2; checkpoint kinase 2; γ-H2AX; phosphorylated histone H2AX at Ser 139; LA-12; (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV); PARP; poly (ADP-ribose) polymerase; PBS; phosphate-buffered
G2/M cell cycle arrest on HT-29 cancer cells and toxicity assessment of triphenylphosphanegold(I) carbonimidothioates, Ph3PAu[SC(OR)Â =Â NPh], RÂ =Â Me, Et, and iPr, during zebrafish development
Keywords: بازرسی کیناز 1; Annexin V-FITC; Recombinant annexin V conjugated to fluorescein isothiocyanate; APAF-1; Apoptotic protease activating factor 1; ATR; Ataxia telangiectasia and Rad3-related; Bax; Apoptosis regulator; Bcl-2; B-cell lymphoma 2; BIRC-5; Baculoviral inhibitor
QSAR study of pyrazolo[1,5-a]pyrimidine derivative inhibitors of Chk1
Keywords: بازرسی کیناز 1; Checkpoint kinase 1; Quantitative structure–activity relationship; Particle swarm optimization; Support vector machine
Mdc1 modulates the interaction between TopBP1 and the MRN complex during DNA damage checkpoint responses
Keywords: بازرسی کیناز 1; Mdc1; TopBP1; MRN complex; Nbs1; DNA damage checkpoint; DSB; double-stranded DNA break; Mdc1; mediator of DNA damage checkpoint protein 1; Chk1; checkpoint kinase 1; ATM; ataxia-telangiectasia mutated; ATR; ATM and Rad3-related; IR; ionizing radiation; si
PKC-alpha modulation by miR-483-3p in platinum-resistant ovarian carcinoma cells
Keywords: بازرسی کیناز 1; API5; apoptosis inhibitor 5; ARF1; ADP ribosylation factor 3; BCA; bicinchoninic acid; BBC3/PUMA; BCL2 binding component 3; BIRC5; baculoviral IAP (inhibitor of apoptosis) repeat containing 5; CDC25A; cell division cycle 25A; CDK4; cyclin-dependent kinase
Research ArticleHepatitis B virus induces RNR-R2 expression via DNA damage response activation
Keywords: بازرسی کیناز 1; HBV; hepatitis B virus; dNTPs; deoxyribonucleotide triphosphates; Chk1; checkpoint kinase 1; RNR; ribonucleotide reductase; DDR; DNA damage response; PHH; primary human hepatocytes; SDS-PAGE; sodium dodecyl sulfate polyacrylamide gel electrophoresis; qRT-
Research ArticleHepatitis C virus-mediated Aurora B kinase inhibition modulates inflammatory pathway and viral infectivity
Keywords: بازرسی کیناز 1; HCV; hepatitis C virus; HCC; hepatocellular carcinoma; AURKB; Aurora B kinase; PP2; protein phosphatase 2; Chk1; checkpoint kinase 1; NF-κB; nuclear factor-κB; COX-2; cyclooxygenase-2; Hepatitis C; Inflammation; NF-κB; COX-2; Histone modifications;
ATR signaling cooperates with ATM in the mechanism of low dose hypersensitivity induced by carbon ion beam
Keywords: بازرسی کیناز 1; IR; ionizing radiation; LET; linear energy transfer; HRS; hyper-radiosensitivity; IRR; induced radioresistance; DSB; DNA double strand break; ATM; ataxia telangiectasia mutated homolog; ATR; ataxia telangiectasia and Rad3 related; DNA-PKcs; DNA-dependent
Platinum-induced kidney damage: Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury
Keywords: بازرسی کیناز 1; ApG; adenine-guanine; ATM; Ataxia telangiectasia mutated; ATR; ATM and Rad3 related kinase; Bax; Bcl2-associated X protein; Bcl2; B-cell CLL/lymphoma 2; EdU; 5-ethynyl-2â²-deoxyuridine; CarboPt; carboplatin; CENP-F; centromere protein F; Chk1; checkpoint
CHEK again: Revisiting the development of CHK1 inhibitors for cancer therapy
Keywords: بازرسی کیناز 1; CHK1; Checkpoint kinase 1; DNA replication; WEE1; DNA damage responseATM, ataxia-telangiectasia mutated; ATR, ATM and Rad3 related; CHK1, Checkpoint Kinase 1; CHK2, Checkpoint Kinase 2; CDKs, Cyclin-dependent kinases; DDK, DBF4/DRF1-dependent CDC7 kinase;
Opportunities for translation: Targeting DNA repair pathways in pancreatic cancer
Keywords: بازرسی کیناز 1; ATR; ATM-Rad3-related; BER; base excision repair; Chk1; checkpoint kinase 1; DDR; DNA damage response and repair; DNA-PKcs; DNA-PK catalytic subunit; DOT1L; DOT1-like; DSB; double strand break; FOLFIRINOX; folinic acid, 5-FU, irinotecan, oxaliplatin; 5-FU
Applications of NMR screening techniques to the pharmaceutical target Checkpoint kinase 1
Keywords: بازرسی کیناز 1; AEBSF; 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride; Chk1; Checkpoint kinase 1; DIRECTION; Difference of Inversion REcovery rate with and without Target IrradiatiON; DSBs; double strand breaks; HEPES; 4-(2-HydroxyEthyl)-1-PiperazineEthaneSulfoni
A site-selective, irreversible inhibitor of the DNA replication auxiliary factor proliferating cell nuclear antigen (PCNA)
Keywords: بازرسی کیناز 1; APC; allophycocyanin; ATR; ataxia telangiectasia mutated and rad3-related; BCA; bicinchoninic acid; Chk1; checkpoint kinase 1; CSK buffer; cytoskeleton buffer; DBU; 1,8-diazabicyclo[5.4.0]undec-7-ene; DCM; dichloromethane; DIPEA; N,N-diisopropylethylamine
A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway
Keywords: بازرسی کیناز 1; Kinase inhibitor; p53 Pathway activation; Casein kinase 1; Checkpoint kinase 1;
Checkpoint kinase 1 inhibitors for potentiating systemic anticancer therapy
Keywords: بازرسی کیناز 1; Cell cycle checkpoints; Checkpoint kinase 1; Checkpoint kinase 2; Chemopotentiation; DNA damage response
Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors
Keywords: بازرسی کیناز 1; Triazolones; CHK1; Checkpoint kinase 1; In vivo activity
Disruptive cell cycle regulation involving epigenetic downregulation of Cdkn2a (p16Ink4a) in early-stage liver tumor-promotion facilitating liver cell regeneration in rats
Keywords: بازرسی کیناز 1; BNF; β-naphthoflavone; Cdc2; cell division cycle 2; Cdc25c; cell division cycle 25 homolog C (S. pombe); Cdk; cyclin-dependent kinase; Chk1; checkpoint kinase 1; CKI; cyclin-dependent kinase inhibitor; DEN; N-diethylnitrosamine; FB; fenbendazole; γH2AX;
Transient knock down of checkpoint kinase 1 in hematopoietic progenitors is linked to bone marrow toxicity
Keywords: بازرسی کیناز 1; Checkpoint kinase 1; Bone marrow suppression; RNAi;
Characterization of novel Checkpoint kinase 1 inhibitors by in vitro assays and in human cancer cells treated with topoisomerase inhibitors
Keywords: بازرسی کیناز 1; Checkpoint kinase 1; Camptothecin; Mitosis; DNA damage; Checkpoint adaptation; Cell cycle;
Synthesis of selenophene derivatives as novel CHK1 inhibitors
Keywords: بازرسی کیناز 1; Checkpoint kinase 1; CHK1 inhibitor; Kinase; Selenophene; Indolin-2-one
HTLV-1 Tax: Linking transformation, DNA damage and apoptotic T-cell death
Keywords: بازرسی کیناز 1; AP-1; activator protein 1; APC; anaphase promoting complex; ATL; adult T-cell leukemia; ATM kinase; ataxia telangiectasia mutated kinase; BES; base excision repair; Chk1; checkpoint kinase 1; Chk2; checkpoint kinase 2; CREB; cyclic AMP response element-bi
An unusual DNA binding compound, S23906, induces mitotic catastrophe in cultured human cells
Keywords: بازرسی کیناز 1; CPT, camptothecin; CDDP, cisplatin; Cdk1, cyclin-dependent kinase 1; Chk1, checkpoint kinase 1Cytotoxic drug; Cyclin-dependent kinases; Cdk1; DNA damage response; Checkpoint kinase 1; Histone γ-H2AX; Checkpoint adaptation
Synthesis and biological evaluation of 4′-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors
Keywords: بازرسی کیناز 1; Checkpoint kinase 1; Chk1 inhibitor; Kinase; DNA damage; DNA repair; Pyrazole; Antitumor; Cancer
Discovery of 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles and 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridine-2′-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors
Keywords: بازرسی کیناز 1; Antitumor agent; Chk1 inhibitors; Checkpoint kinase 1; Pyrazole; Structure–activity relationship; DNA damage; Combination therapy
Macrocyclic ureas as potent and selective Chk1 inhibitors: An improved synthesis, kinome profiling, structure–activity relationships, and preliminary pharmacokinetics
Keywords: بازرسی کیناز 1; Checkpoint kinase 1; Chk1; Ureas; Kinase inhibitors; Macrocycles; Ring-closure metathesis; DNA damage
The Drosophila melanogaster DmCK2β transcription unit encodes for functionally non-redundant protein isoforms
Keywords: بازرسی کیناز 1; a.e.; after eclosion; cDNA; DNA complementary to RNA; CHK1; checkpoint kinase 1; CHK2; checkpoint kinase 2; CK2; casein kinase 2; Dm; Drosophila melanogaster; ds; double-stranded; GT; gene trap; h; hour; HA; hemagglutinin; HEK; human embryonic kidney; mbu
Geldanamycin-induced degradation of Chk1 is mediated by proteasome
Keywords: بازرسی کیناز 1; Checkpoint kinase 1; Glioblastoma; Geldanamycin; Ubiquitin; Proteasome;