Keywords: Apaf-1; Apoptotic protease-activating factor-1; A498; Renal proximal tubular carcinoma; BCA; Bicinchoninic acid; Bax; Bcl-2 associated X protein; Bcl-2; B-cell lymphoma 2; BSA; Bovine Serum Albumin; Cdc25; Cell-division control protein 25(Dual-Specificity
مقالات ISI (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: GBM; glioblastoma; LGG; lower-grade glioma; CNS; central nervous system; DA; diffused astrocytoma; AA; anaplastic astrocytoma; WHO; World Health Organization; RPPA; reverse phase protein array; TCGA; the cancer genome atlas; IDH; isocitrate dehydrogenase;
Keywords: 4EBP1; Eukaryotic Translation Initiation Factor 4E Binding Protein 1; ATF3; activating transcription factor 3; ATM; Ataxia Telangiectasia Mutated; ATR; Ataxia Telangiectasia and Rad3-Related; ARF; alternative reading frame; BAPTA; 1,2-bis(o-aminophenoxy)e
Keywords: ATIR; anti-tumor immune response; ATM; ataxia telangiectasia mutated; CDK; cyclin-dependent kinase; CGH; comparative genomic hybridization; CHK1; checkpoint kinase 1; CHK2; checkpoint kinase 2; DDAs; DNA-damaging agents; DDR; DNA damage response; DSBs; do
Keywords: 3-MA; 3-methyladenine; Asc; ascorbate; ATM; ataxia telangiectasia mutated; ATP; adenosine triphosphate; BRAF; murine sarcoma viral oncogene homolog B; Cat; catalase; Chk2; checkpoint kinase 2; CQ; chloroquine; Cys-SO3H; cysteine S-sulfate; DHA; dehydroasc
Keywords: ACLY; ATP-citrate lyase; ATM; ataxia telangiectasia mutated; BCL-2; B-cell leukemia-2; Chk2; checkpoint homolog kinase 2; CiC; citrate carrier; DIC; dicarboxylate carrier; DNMT; DNA methyltransferase; FH; fumarate hydratase; H3K27; histone 3 lysine 27; HA
Keywords: AMPPNP; adenylylimidodiphosphate; AUC; analytical ultracentrifugation; βME; β-mercaptoethanol; Chk2; checkpoint kinase 2; DAPK3; Death-associated protein kinase 3; DTT; dithiothreitol; FHA; forkhead-associated; HU; hydroxyurea; IPTG; Isopropyl β-d-1-th
Keywords: ATM; ataxia telangiectasia mutated; ATP; adenosine triphosphate; Chk2; checkpoint kinase 2; DNA-PKcs; DNA-dependent protein kinase catalytic subunit; DUSP; dual-specificity phosphatase; HIV; human immunodeficiency virus; IL; interleukin; MCP1; monocyte ch
Keywords: Chk2; Drug design; Pharmacophore; Virtual screening;
Melanoma antigen-D2 controls cell cycle progression and modulates the DNA damage response
Keywords: APC/C; anaphase-promoting complex or cyclosome; ATM; ataxia-telangiectasia mutated protein; ATR; ataxia-telangiectasia- and rad3-related protein; CDC20; cell division cycle protein 20; CDK; cyclin-dependent kinase; CHK1; checkpoint kinase 1; CHK2; checkpo
CCRK is a novel signalling hub exploitable in cancer immunotherapy
Keywords: 9G8; serine and arginine rich splicing factor 7; AKT; AKT serine/threonine kinase; AR; androgen receptor; ARE; androgen response element; ARG1; arginase 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and rad3-related protein; BMDC; mous
DNA damage and repair proteins in cellular response to sulfur mustard in Iranian veterans more than two decades after exposure
Keywords: CHK1; checkpoint kinase 1 human protein; CHK2; checkpoint kinase 2 human protein; COPD; chronic obstructive pulmonary disease; DSB; double-strand breaks; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GSH; glutathione; γH2AX; phosphorylated H2AX; MRN;
DNA repair mechanisms in response to genotoxicity of warfare agent sulfur mustard
Keywords: ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and rad3 related; BER; base excision repair; Cdc25; cell division cycle 25; CDKs; cyclin-dependent kinases; CEES; 2-chloroethyl ethyl sulphide; ChK1; checkpoint kinase 1; Chk2; checkpoint kina
Therapeutic management of peritoneal ascitic sarcomatosis by Ruta graveolens: A study in experimental mice
Keywords: Peritoneal sarcomatosis; Chemotherapy; c-Myc; Chk2; CD 95;
Reverting p53 activation after recovery of cellular stress to resume with cell cycle progression
Keywords: AMPK; AMP - activate kinase alpha 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related protein; CHK2; checkpoint kinase 2; CHK1; checkpoint kinase 1; CDK; cyclin-dependent kinase; CDKN2A; cyclin dependent kinase inhibitor 2A;
RA-Induced Transcriptional Silencing of Checkpoint Kinase-2 through Promoter Methylation by Dnmt3b Is Required for Neuronal Differentiation of P19 Cells
Keywords: DNA methylation; checkpoint kinase 2; DNA methyltransferase 3b; P19 cells; bisulfite genomic sequencing; RA; retinoic acid; Dnmt; DNA methyltransferase; Chk2; checkpoint kinase 2; ChIP; chromatin immunoprecipitation; BGS; bisulfite genomic sequence; PBS;
Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells
Keywords: CDDP; cisplatin; Chk1; checkpoint kinase 1; Chk2; checkpoint kinase 2; γ-H2AX; phosphorylated histone H2AX at Ser 139; LA-12; (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV); PARP; poly (ADP-ribose) polymerase; PBS; phosphate-buffered
Cataractogenesis following high-LET radiation exposure
Keywords: A-bomb; atomic bomb; amu; atomic mass unit; ATM; ataxia telangiectasia mutated; BNCT; boron neutron capture therapy; BPA; boronophenylalanine; BSH; sodium borocaptate; CDK1; cyclin dependent kinase 1; CDKN1A; cyclin dependent kinase inhibitor 1A; CHK2; ch
Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs
Keywords: Indirubin; Meisoindigo; Pancreatic cancer stem cell; CSC drug; LKB1 inactivation; AMPK activation; PDAC; CD133; 2-DG; 2-deoxyglucose; ACC; acetyl-CoA carboxylase; AMPK; 5â² AMP-activated protein kinase; CHK2; check point kinase 2; DM; Dorsomorphin; ESA;
PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer
Keywords: A1AR; adenosine A1 receptor; ABC transporters; ATP-binding cassette; ABCB1/P-gp/MDR1; P-glycoprotein; ABCG2/BCRP; breast cancer resistant protein; Ang-1; angiopoietin 1; ASCs; Adipose stem cells; Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma extra-lar
Platinum-induced kidney damage: Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury
Keywords: ApG; adenine-guanine; ATM; Ataxia telangiectasia mutated; ATR; ATM and Rad3 related kinase; Bax; Bcl2-associated X protein; Bcl2; B-cell CLL/lymphoma 2; EdU; 5-ethynyl-2â²-deoxyuridine; CarboPt; carboplatin; CENP-F; centromere protein F; Chk1; checkpoint
Checkpoint kinase 2 (Chk2) supports sensitivity to platinum-based treatment in high grade serous ovarian cancer
Keywords: DNA damage response; Ovarian cancer; Platinum-based chemotherapy; Chk2; Chemoresistance
4′-Demethyl-deoxypodophyllotoxin glucoside isolated from Podophyllum hexandrum exhibits potential anticancer activities by altering Chk-2 signaling pathway in MCF-7 breast cancer cells
Keywords: Podophyllum hexandrum; Cytotoxicity; Chk2; G2/M arrest; Breast cancer
Aurora-A controls cancer cell radio- and chemoresistance via ATM/Chk2-mediated DNA repair networks
Keywords: Aur-A; Aurora-A cDNA-infected cells; Aur-Ai; Aurora-A shRNA-infected cells; BRCA1i; BRCA1 shRNA-infected cells; BRCA2i; BRCA2 shRNA-infected cells; Scr; scrambled shRNA-infected cells; IR; Irradiation; Cis; Cisplatin; KU; KU-55933, the inhibitor of ATM; A
SKLB316, a novel small-molecule inhibitor of cell-cycle progression, induces G2/M phase arrest and apoptosis in vitro and inhibits tumor growth in vivo
Keywords: chk2; check point kinase 2; CDK1; cyclin-dependent kinase 1; ROS; reactive oxygen species; TUNEL; terminal deoxynucleotidyl transferase dUTP nick end labeling; DMSO; dimethyl sulfoxide; MTT; 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide; P
Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells
Keywords: CRC; colorectal cancer; CPT; camptothecin; DSBs; double-strand breaks; DDR; DNA damage response; γ-H2AX; phosphorylated histone H2AX; ATM; ataxia telangiectasia mutated; Chk2; check-point kinase; AMPK; AMP-activated protein kinase; TSC2; tuberous scleros
γH2AX foci formation in the absence of DNA damage: Mitotic H2AX phosphorylation is mediated by the DNA-PKcs/CHK2 pathway
Keywords: γH2AX; CHK2; DNA-PKcs; DNA damage; Mitosis;
CHK2 1100delC, IVS2 + 1G>A and I157T mutations are not present in hepatocellular cancer cases from a Turkish population
Keywords: HCC, Hepatocellular carcinoma; CHK2, cell cycle checkpoint kinase 2; PCR–RFLP, polymerase chain reaction–restriction fragment length polymorphism; AS-PCR, allele specific-polymerase chain reactionHepatocellular carcinoma; CHK2; CHK2 1100delC; IVS2 + 1G>A
Oroxylin A reverses P-glycoprotein-mediated multidrug resistance of MCF7/ADR cells by G2/M arrest
Keywords: MCF7/ADR, Adriamycin resistant human breast cancer cell line; MDR, multidrug resistance; Chk2, checkpoint kinase 2; NF-κB, nuclear factor-kappa B; PMSF, phenylmethylsulfonyl fluorideOroxylin A; MCF7/ADR; G2/M; P-gp; Chk2
A multicancer-like syndrome in a dog characterized by p53 and cell cycle-checkpoint kinase 2 (CHK2) mutations and Sirtuin gene (SIRT1) down-regulation
Keywords: SIRT1; p53; CHK2; Melanoma; Dog
Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors
Keywords: Checkpoint kinases; Chk2; Natural products; Debromohymenialdisine; Hymenialdisine; Radioprotection;
The BRCA1 alternative splicing variant Î14-15 with an in-frame deletion of part of the regulatory serine-containing domain (SCD) impairs the DNA repair capacity in MCF-7 cells
Keywords: ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related; AURKA; Aurora kinase A; BC; breast cancer; BRCA1/2; breast cancer-associated gene 1/2; BRCT; BRCA1 C-terminal domain; B2M; beta-2-microglobulin; Cdk2; cyclin-dependent kinase
Benzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and protein-ligand crystallography
Keywords: ADP; adenosine diphosphate; ATM; ataxia telangiectasia mutated; ATP; adenosine triphosphate; CHK2; checkpoint kinase 2; GOLD; genetic optimisation for ligand docking; GST; glutathione S-transferase; KD; kinase domain; MOE; molecular operating environment;
The HDAC inhibitor depsipeptide transactivates the p53/p21 pathway by inducing DNA damage
Keywords: Ara-C; cytarabine; ATM; ataxiatelangiectasia-mutated; ATR; ATM- and Rad3-related; CAT; catalase; CHK2; the checkpoint kinase 2; CK1; casein kinase 1; DHE; dihydroethidium; DNA-PK; DNA-dependent serine/threonine protein kinase; Grx; glutaredoxin; HAT; hist
TIS21/BTG2/PC3 accelerates the repair of DNA double strand breaks by enhancing Mre11 methylation and blocking damage signal transfer to the Chk2T68-p53S20 pathway
Keywords: TIS21; TPA inducible sequence 21; DSBs; DNA double strand breaks; TIS21â/âMEF; TIS21 knockout mouse embryo fibroblast; wt-MEF; wild type mouse embryo fibroblast; PRMT1; protein arginine methyltransferase 1; Mre11; meiotic recombination 11; Chk2; check
ALCAPs induce mitochondrial apoptosis and activate DNA damage response by generating ROS and inhibiting topoisomerase I enzyme activity in K562 leukemia cell line
Keywords: γH2AX; modified and phosphorylated histone 2A; ATM; ataexia telangiectasia mutated; PARP; poly-ADP ribose polymerase; CHK2; checkpoint kinase 2; CPT-11; irinotecan; Doxo; doxorubicin; l-NAC; l-N-acetyl-cysteine; ROS; Topoisomerase I inhibition; γH2AX; A
Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition
Keywords: PARP inhibitor; Methyl methanesulfonate; NBS1; SMC1; Cell cycle; Chk1; Chk2
Chk2-mediated G2/M cell cycle arrest maintains radiation resistance in malignant meningioma cells
Keywords: Meningioma; Radiotherapy; G2/M cell cycle arrest; Chk2
Per3, a circadian gene, is required for Chk2 activation in human cells
Keywords: Circadian clock; Per3; Cell cycle checkpoint; Chk2; DNA damagePer, period; Chk, checkpoint kinase; ATM, ataxia telangiectasia mutated
Fenofibrate antagonizes Chk2 activation by inducing Wip1 expression: Implications for cell proliferation and tumorigenesis
Keywords: Fenofibrate; Wip1; Chk2; G2/M arrest; Cell proliferation; Tumorigenesis
Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation
Keywords: ERK1/2 kinases; DNA damage response (DDR); ATM; CHK2; CDC25C; G2/M arrest;
HTLV-1 Tax: Linking transformation, DNA damage and apoptotic T-cell death
Keywords: AP-1; activator protein 1; APC; anaphase promoting complex; ATL; adult T-cell leukemia; ATM kinase; ataxia telangiectasia mutated kinase; BES; base excision repair; Chk1; checkpoint kinase 1; Chk2; checkpoint kinase 2; CREB; cyclic AMP response element-bi
Chk2 down-regulation by promoter hypermethylation in human bulk gliomas
Keywords: Glioma; Chk2; Promoter; Methylation; Sp1
Enzastaurin induces H2AX phosphorylation to regulate apoptosis via MAPK signalling in malignant glioma cells
Keywords: Enzastaurin; PKC; H2AX; Chk2; Apoptosis; Glioma;
The Effects of G2-Phase Enrichment and Checkpoint Abrogation on Low-Dose Hyper-Radiosensitivity
Keywords: Ionizing radiation; Low dose; Cell cycle; G2 checkpoint arrest; Chk1; Chk2;
Chk2 splice variants express a dominant-negative effect on the wild-type Chk2 kinase activity
Keywords: Chk2; checkpoint kinase 2; Chk2wt; Chk2 wild-type; FHA domain; fork-head associated domain; KD; kinase dead; LFS; Li-Fraumeni syndrome; RF; reading frame; SCD; SQ/TQ cluster domain; TP53; p53 tumor suppressor gene; Chk2; Splicing; Breast cancer;
Structure-guided expansion of kinase fragment libraries driven by support vector machine models
Keywords: FBDD; fragment-based drug design; SBDD; structure-based drug design; QSAR; quantitative structure activity relationship; SVM-FP; support vector machine-fingerprints; PPV; positive predicted value; LE; ligand efficiency; HAC; heavy atom count; AMW; atomi
A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage
Keywords: Cell cycle checkpoints; DNA damage responses; Chk2; Kinase inhibitors; Protein phosphatases
Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2
Keywords: CHK2; Kinase inhibitor; High-throughput screening; Crystallography
Telomere length, telomeric proteins and DNA damage repair proteins are differentially expressed between primary lung tumors and their adrenal metastases
Keywords: DNA; Deoxyribonucleic acid; DDR; DNA damage repair; ATM; Ataxia telangictasia mutated; ATR; Ataxia telangiectasia related; CHK2; Checkpoint Kinase 2; γ-H2AX; Phosphorylated histone H2A variant H2AX; BSA; bovine serum albumin; PNA; peptide nucleic acid; M