کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8456471 | 1548596 | 2014 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MicroRNAs as potential biomarkers in diseases and toxicology
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: MicroRNAs as potential biomarkers in diseases and toxicology MicroRNAs as potential biomarkers in diseases and toxicology](/preview/png/8456471.png)
چکیده انگلیسی
MiRNAs (microRNAs) are single-stranded non-coding RNAs of approximately 21-23 nucleotides in length whose main function is to inhibit gene expression by interfering with mRNA processes. MicroRNAs suppress gene expression by affecting mRNA (messenger RNAs) stability, targeting the mRNA for degradation, or both. In this review, we have examined how microRNA expression could be altered following exposure to chemicals and how they could represent appropriate tissue and more interestingly circulating biomarkers. Among the key questions before using the microRNA for evaluation of risk toxicity, it remains still to clarify how they could be causally involved in the adverse effects and how stable their changes are.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volumes 764â765, April 2014, Pages 46-57
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volumes 764â765, April 2014, Pages 46-57
نویسندگان
Bénazir Siddeek, Lilia Inoubli, Nadjem Lakhdari, Paul Bellon Rachel, Karma Claire Fussell, Steffen Schneider, Claire Mauduit, Mohamed Benahmed,