Exposure of pregnant mice to carbon black by intratracheal instillation: Toxicogenomic effects in dams and offspring

► Developmental effects of exposure to carbon black particles in utero were examined. ► The pulmonary transcriptome of dams was profiled against offspring hepatic response. ► Response in dams was marked by prolonged inflammation and particle retention. ► Female offspring were more sensitive to in utero carbon black exposure than males. ► We speculate that responses in newborns are secondary to inflammation in dams.