Merging nano-genotoxicology with eco-genotoxicology: An integrated approach to determine interactive genotoxic and sub-lethal toxic effects of C60 fullerenes and fluoranthene in marine mussels, Mytilus sp.

► C60 fullerenes (C60) and fluoranthene induce DNA breaks in haemocytes of mussels. ► Combination of C60 and fluoranthene enhance DNA breaks and glutathione level. ► No DNA adducts formation after exposure to C60 and fluoranthene in mussel tissues. ► C60 alone or with fluoranthene impact physiology and histology of mussel tissues. ► C60 accumulates in organs, more in digestive gland; more without fluoranthene.