Bimolane induces multiple types of chromosomal aberrations in human lymphocytes in vitro

► Bimolane, a leukemia-inducing agent, was genotoxic to human lymphocytes in vitro. ► Both the synthesized and commercially available drug induced the following. ► Chromosomal breakage resulting in micronuclei and dicentric chromosomes. ► Aneuploidy as manifested by chromosome loss and non-disjunction. ► Polyploidy due to mitotic slippage, endoreduplication and binucleation.