کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8456694 | 1548740 | 2018 | 45 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Assessing health risks from multiple environmental stressors: Moving from GÂ ÃÂ E to IÂ ÃÂ E
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Assessing health risks from multiple environmental stressors: Moving from GÂ ÃÂ E to IÂ ÃÂ E Assessing health risks from multiple environmental stressors: Moving from GÂ ÃÂ E to IÂ ÃÂ E](/preview/png/8456694.png)
چکیده انگلیسی
Research on disease causation often attempts to isolate the effects of individual factors, including individual genes or environmental factors. This reductionist approach has generated many discoveries, but misses important interactive and cumulative effects that may help explain the broad range of variability in disease occurrence observed across studies and individuals. A disease rarely results from a single factor, and instead results from a broader combination of factors, characterized here as intrinsic (I) and extrinsic (E) factors. Intrinsic vulnerability or resilience emanates from a variety of both fixed and shifting biological factors including genetic traits, while extrinsic factors comprise all biologically-relevant external stressors encountered across the lifespan. The IÂ ÃÂ E concept incorporates the multi-factorial and dynamic nature of health and disease and provides a unified, conceptual basis for integrating results from multiple areas of research, including genomics, GÂ ÃÂ E, developmental origins of health and disease, and the exposome. We describe the utility of the IÂ ÃÂ E concept to better understand and characterize the cumulative impact of multiple extrinsic and intrinsic factors on individual and population health. New research methods increasingly facilitate the measurement of multifactorial and interactive effects in epidemiological and toxicological studies. Tiered or indicator-based approaches can guide the selection of potentially relevant I and E factors for study and quantification, and exposomics methods may eventually produce results that can be used to generate a response function over the life course. Quantitative data on IÂ ÃÂ E interactive effects should generate a better understanding of the variability in human response to environmental factors. The proposed IÂ ÃÂ E concept highlights the role for broader study design in order to identify extrinsic and intrinsic factors amenable to interventions at the individual and population levels in order to enhance resilience, reduce vulnerability and improve health.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Reviews in Mutation Research - Volume 775, JanuaryâMarch 2018, Pages 11-20
Journal: Mutation Research/Reviews in Mutation Research - Volume 775, JanuaryâMarch 2018, Pages 11-20
نویسندگان
Cliona M. McHale, Gwendolyn Osborne, Rachel Morello-Frosch, Andrew G. Salmon, Martha S. Sandy, Gina Solomon, Luoping Zhang, Martyn T. Smith, Lauren Zeise,