کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8456723 | 1548754 | 2014 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis
ترجمه فارسی عنوان
تداخل بین نگهداری تلومر و اثرات تابش: یک بازیکن کلیدی در فرایند سرطان زایی ناشی از تابش
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کلمات کلیدی
تلومرها، تابش یونیزه، تاثیر متقابل، حساسیت رادیویی، بی ثباتی کروموزومی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
It is well established that ionizing radiation induces chromosomal damage, both following direct radiation exposure and via non-targeted (bystander) effects, activating DNA damage repair pathways, of which the proteins are closely linked to telomeric proteins and telomere maintenance. Long-term propagation of this radiation-induced chromosomal damage during cell proliferation results in chromosomal instability. Many studies have shown the link between radiation exposure and radiation-induced changes in oxidative stress and DNA damage repair in both targeted and non-targeted cells. However, the effect of these factors on telomeres, long established as guardians of the genome, still remains to be clarified. In this review, we will focus on what is known about how telomeres are affected by exposure to low- and high-LET ionizing radiation and during proliferation, and will discuss how telomeres may be a key player in the process of radiation-induced carcinogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Reviews in Mutation Research - Volume 760, AprilâJune 2014, Pages 1-17
Journal: Mutation Research/Reviews in Mutation Research - Volume 760, AprilâJune 2014, Pages 1-17
نویسندگان
Grace Shim, Michelle Ricoul, William M. Hempel, Edouard I. Azzam, Laure Sabatier,