کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8457410 1548807 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of brain-derived neurotrophic factor and its single nucleotide polymorphisms in stroke patients
ترجمه فارسی عنوان
نقش عامل فاکتور نوروتروفی مشتق شده مغز و پلیمورفیسم تک نوکلئوتیدی آن در بیماران سکته مغزی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی
Several single nucleotide polymorphisms of the BDNF gene have been studied with regard to stroke patients, but most papers analyse the rs6265 which results in a change from valine to methionine in the precursor protein. Subsequently a reduction in BDNF activity is observed. There are studies indicating the role of this polymorphism in brain plasticity, functional and morphological changes in the brain. It may affect the risk of ischemic stroke, post-stroke outcomes and the efficacy of the rehabilitation process within physical exercise and transcranial magnetic stimulation. There is a consistent trend of Met alleles' being connected with worse outcomes and prognoses after stroke. However, there is no satisfactory data confirming the importance of Met allele in stroke epidemiology and the post-stroke rehabilitation process. We present the current data on the role of BDNF and polymorphisms of the BDNF gene in stroke patients, concentrating on human studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurologia i Neurochirurgia Polska - Volume 51, Issue 3, May–June 2017, Pages 240-246
نویسندگان
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