کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8457564 1548814 2018 29 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Predicting response to sepantronium bromide (YM155), a survivin suppressant, by PET imaging with [11C]YM155
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Predicting response to sepantronium bromide (YM155), a survivin suppressant, by PET imaging with [11C]YM155
چکیده انگلیسی
The concept that tumor response can be accurately predicted prior to chemotherapy should be exploited to improve cancer treatment outcomes through judicious patient selection. The small molecule sepantronium bromide (YM155), a survivin suppressant, has been developed for the treatment of several cancers, including non-Hodgkin lymphoma, lung cancer, and breast cancer. The preferentially high in vitro uptake of YM155 by YM155-sensitive cancer cells and the high in vivo uptake of [11C]YM155 in YM155-sensitive tumors demonstrated by PET imaging suggest the potential utility of performing [11C]YM155 PET to allow the identification of patients with YM155-sensitive tumors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Medicine and Biology - Volumes 64–65, September–October 2018, Pages 41-46
نویسندگان
, , , , , , , ,