The function of long non-coding RNA MT1JP in the development and progression of gastric cancer

LncRNA MT1JP overexpression vector was constructed and then transfected into gastric cancer cells. Further CCK-8 and transwell detection showed that lncRNA MT1JP exerted an evident inhibition role on proliferation, migration and invasion. By combining molecular cell biology experiments of the reporter gene, cell overexpression or interference and Western blot, we found that lncRNA MT1JP may regulate FBXW7 expression involved in the occurrence and development of gastric cancer. The results of this study not only explain the role of lncRNA MT1JP in the development of gastric cancer, but also provide important ideas and clues for the study of genetic regulation mechanism in gastric cancer.