کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8458003 | 1548864 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
COX-2 as a determinant of lower disease-free survival for patients affected by ameloblastoma
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: COX-2 as a determinant of lower disease-free survival for patients affected by ameloblastoma COX-2 as a determinant of lower disease-free survival for patients affected by ameloblastoma](/preview/png/8458003.png)
چکیده انگلیسی
Ameloblastoma is a locally aggressive neoplasm with a poorly understood pathogenesis. Therefore, the aim of this study is to investigate whether COX-2 expression is associated with ameloblastoma microvascular density (MVD) and with tumor aggressiveness. Sixty-three cases of primary ameloblastomas arranged in tissue microarray were submitted to immunohistochemistry against cyclooxigenase-2 (COX-2) and CD34. Clinicopathological parameters regarding sex, age, tumour size, tumour duration, tumour location, treatment, recurrences, radiographic features, vestibular/lingual and basal cortical disruption and follow-up data were obtained from patients' medical records and correlated with the proteins expression. The results on BRAF-V600E expression were obtained from our previous study and correlated with COX-2 and CD34 expressions. Log-rank univariate analysis and multivariate Cox regression model were done to investigate the prognostic potential of the molecular markers. Twenty-eight cases (44.4%) exhibited cytoplasmic positivity for COX-2, predominantly in the columnar peripheral cells, with a mean MVD of 2.2 vessels/mm2. COX-2 was significantly associated with recurrences (pâ¯<â¯0.001) and BRAF-V600E expression (pâ¯<â¯0.001), whereas lower MVD was associated with the use of conservative therapy (pâ¯=â¯0.004). Using univariate and multivariate analyses, COX-2 was significantly associated with a lower 5-year disease-free survival (DFS) rate (pâ¯<â¯0.001 and pâ¯=â¯0.012, respectively), but not with a higher MVD (pâ¯=â¯0.68). In conclusion, COX-2 expression in ameloblastomas is not associated with MVD, but it is significantly associated with recurrences and with a lower DFS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Research and Practice - Volume 214, Issue 6, June 2018, Pages 907-913
Journal: Pathology - Research and Practice - Volume 214, Issue 6, June 2018, Pages 907-913
نویسندگان
Marco Aurélio Petroni Montezuma, Felipe Paiva Fonseca, Bernar Monteiro Benites, Ciro Dantas Soares, Gleyson Kleber do Amaral-Silva, Oslei Paes de Almeida, Fernando Augusto Soares, Rosana Lima Pagano, Eduardo Rodrigues Fregnani,