کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8458107 | 1548866 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The degree of overlap between the follicular dendritic cell meshwork and tumor cells in mantle cell lymphoma is associated with prognosis
ترجمه فارسی عنوان
درجه همپوشانی بین سلول های سلولی دندریتیک فولیکولی و سلول های تومور در لنفوم سلولی مانت با پیش آگهی همراه است
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
This study concerning mantle cell lymphoma (MCL) investigated retrospectively an association between patient prognosis and the percentage of the total number of lymphoma cells found in the follicular dendritic cell (FDC) meshwork, that is, the degree of overlap of lymphoma cells. Two hundred and nine MCL patients were apportioned to grades I-III, in which the CD21-positive FDC meshwork covered â¤50%, 51%-89%, and â¥90% of the tumor area, respectively. Significant differences among the grades (all, Pâ¯<â¯0.01) were found in the following: duration of disease (from onset of clinical manifestation to diagnosis); clinical staging; extranodal involvement (non-lymphoid organs); histological subtype; and Ki-67 proliferation index (PI). After removing the aggressive variants, the overall survival rates of grade I (nâ¯=â¯92) and II (nâ¯=â¯57) patients were similar. The overall survival rates of grade III (nâ¯=â¯46) patients differed from that of grade Iâ¯+â¯II patients (Pâ¯<â¯0.01). The grades negatively correlated with the Ki-67 PI value (râ¯=â¯â0.234, Pâ¯=â¯0.001). At each grade the OSR of patients with Ki-67 PI â¤30% was similar to that of patients with Ki-67 >30%. In the Ki-67 PI â¤30% group, the OSRs of the patients differed significantly among the grades. In the Ki-67 >30% group the OSRs of the grades were similar. The results of multivariate Cox regression analysis showed that the degree of overlap, age and Ki-67 PI was the independent prognostic factors of the OSRs of MCL patients. Our data suggests that MCL patients in whom there was a high degree of overlap between the FDC meshwork and tumor area have a better clinical prognosis. The degree of overlap correlates well with the Ki-67 PI, which can be used to predict the prognosis of patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Research and Practice - Volume 214, Issue 4, April 2018, Pages 513-520
Journal: Pathology - Research and Practice - Volume 214, Issue 4, April 2018, Pages 513-520
نویسندگان
Weihua Hou, Ping Wei, Jianlan Xie, Yuanyuan Zheng, Yanlin Zhang, Xiaoge Zhou,