Determination of the proton RBE in the rat spinal cord: Is there an increase towards the end of the spread-out Bragg peak?

For the relative high fractional doses, the experimental RBE at the distal edge of the proton SOBP is moderately increased. The conventionally applied RBE of 1.1 appears to be valid for the mid-SOBP region, but the higher values occurring more distally could be of clinical significance, especially if critical structures are located in this area. Further in vivo studies at lower fractional doses are urgently required.