Dose-volume effect relationships for late rectal morbidity in patients treated with chemoradiation and MRI-guided adaptive brachytherapy for locally advanced cervical cancer: Results from the prospective multicenter EMBRACE study

Significant correlations were established between late rectal morbidity, overall and single endpoints, and dose-volume (D2cm3, D0.1cm3) and dose-point (DICRU) parameters. A D2cm3 ⩽ 65 Gy is associated with more minor and less frequent rectal morbidity, whereas a D2cm3 ⩾ 75 Gy is associated with more major and more frequent rectal morbidity.