کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8461339 | 1549008 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Zipper-like series of desmosomes supported by subplasmalemmal actin belts in thymic epithelial reticular cells in the rat
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
Remodeling of epithelial tissues requires coordinated cell migration. Most of the mechanisms regulating desmosome assembly and stability in migrating epithelial cells are still unknown. The actin cytoskeleton is a significant component of desmosome assembly and maturation. The association of the actin cytoskeleton with adherens junctions requires additional ultrastructural investigations. A transmission electron microscopic study was performed on five samples of rat thymus. Interepithelial series of desmosomes up to 6.5 μm length were found as were composite series of junctions (tight, adherens, and desmosomes). As a particular feature, subplasmalemmal belts of microfilaments, apparently of actin, ran adjacent to the inner dense plaques of desmosomes, passing beneath and at a distance to the tight junctions. They were not found beneath the adherens junctions. The series of desmosomes were termed zipper-like desmosomes (ZLDs), and were either complete, or imperfect. Terminal imperfect or incomplete desmosomes were found at the ends of the zipper-like series. Alpha-smooth muscle actin immune labeling on six other samples of rat thymus was strongly suggestive of the existence of subplasmalemmal actin belts in the epithelial reticular system. Further studies are needed to establish the exact role of the ZLDs during processes of epithelial remodeling.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Anatomy - Anatomischer Anzeiger - Volume 195, Issue 4, July 2013, Pages 359-364
Journal: Annals of Anatomy - Anatomischer Anzeiger - Volume 195, Issue 4, July 2013, Pages 359-364
نویسندگان
M.C. Rusu, F. Pop, V.M. MÄnoiu, M.O. LupuÅoru, A.C. Didilescu,