کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8463886 | 1549403 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Increased immunosuppressive treatment combined with unrelated umbilical cord blood infusion in children with severe aplastic anemia
ترجمه فارسی عنوان
افزایش میزان استفاده از سرکوب ایمنی همراه با تزریق خون بند ناف غیرمستقیم در کودکان مبتلا به کم خونی آپلاستیک
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کلمات کلیدی
کم خونی آپلاستیک درمان با سرکوب سیستم ایمنی خون بند ناف،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
چکیده انگلیسی
A combination treatment of unrelated umbilical cord blood (UCB) and increased immunosuppressive treatment (IST) were investigated to reveal the potentially curative therapy for the severe aplastic anemia (SAA). A total of 36 children (2-17 ages) with SAA who received UCB infusion after an IST were analyzed. The treatment consisted of 100Â mg/kg cyclophosphamide, 12.5-15Â mg/kg antithymocyte globulin and 3Â mg/kg cyclosporine. After 3Â months, the hematologic complete response (CR) rate was 22.2% and partial response (PR) rate was 38.9%. After 6Â months, the CR rate and PR rate was 50.4% and 26.3%, respectively. The probability of 3-year survival was 83.3%. There was no difference in the survival rate either between the horse-ATG and rabbit-ATG or between the SAA and VSAA. The results indicated that the increased IST combined with unrelated UCB infusion has an effective therapeutic potential for children with SAA who lack of compatible donor for transplantation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 289, Issues 1â2, MayâJune 2014, Pages 150-154
Journal: Cellular Immunology - Volume 289, Issues 1â2, MayâJune 2014, Pages 150-154
نویسندگان
Lin-na Xie, Yuan Fang, Zhe Yu, Ning-xia Song, Fan-sheng Kong, Xi-min Liu, Fang Zhou,