Effects of human exogenous DNA on production of perforin-containing CD8+ cytotoxic lymphocytes in laboratory setting and clinical practice

► Polycytostatic treatment results in suppression of tumor growth in mice. ► Human DNA preparation significantly enhances anticancer effects of cytostatic drugs. ► Co-treatment with human DNA and cytostatics activates dendritic cell maturation. ► DNA-activated mature dendritic cells induce development of adaptive immunity. ► Combined therapy increases the number of CD8+/perforin+ T cells in peripheral blood.