کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8464878 1549455 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates
ترجمه فارسی عنوان
چندین سایت اتصال دهنده لیگارد، انتقال دهنده سیگنال خارپشت را در ستون مهره ها تنظیم می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی
The Hedgehog (Hh) pathway plays a central role in the development of multicellular organisms, guiding cell differentiation, proliferation and survival. While many components of the vertebrate pathway were discovered two decades ago, the mechanism by which the Hh signal is transmitted across the plasma membrane remains mysterious. This fundamental task in signalling is carried out by Smoothened (SMO), a human oncoprotein and validated cancer drug target that is a member of the G-protein coupled receptor protein family. Recent structural and functional studies have advanced our mechanistic understanding of SMO activation, revealing its unique regulation by two separable but allosterically-linked ligand-binding sites. Unexpectedly, these studies have nominated cellular cholesterol as having an instructive role in SMO signalling.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Cell Biology - Volume 51, April 2018, Pages 81-88
نویسندگان
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