کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8465820 1549476 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Picking up the threads: extracellular matrix signals in epithelial morphogenesis
ترجمه فارسی عنوان
برداشتن موضوعات: سیگنال های ماتریکس خارج سلولی در مورفوژنز اپیتلیال
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی
Basal adhesion signals are the main driver of epithelial polarization and differentiation. Recent advances are starting to expose a novel and remarkable complexity in extracellular matrix control of epithelial morphogenesis. Mechanical properties such as matrix stiffness and cell confinement are emerging as key regulators of epithelial behavior, modulating cytoskeletal dynamics, which transduce into nuclear signals that regulate differentiation. Moreover, coherent cell migration behaviors, such as organ rotation, control basement membrane secretion and reorganization, and matrix degradation and remodeling are now proposed to be required for proper polarity maintenance and acquisition of organ shape. Furthermore, planar cell polarity components orient all these activities, thus, providing a reasonable explanation for the generation of morphogenetic axes during morphogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Cell Biology - Volume 30, October 2014, Pages 83-90
نویسندگان
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