Sorting out the trash: the spatial nature of eukaryotic protein quality control

- Spatial sequestration of misfolded proteins is an early, normal response to stress.
- PQC compartments spatially restrict misfolded proteins thus enhancing degradation.
- The ER acts as a dynamic network for the spatial distribution of misfolded proteins.
- Spatial protein sequestration promotes rejuvenation of daughter cells in mitosis.
- Altered PQC is associated with neurodegenerative disorders, cancer, and aging.