The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster

►The Hippo pathway controls cell proliferation not only during developmental growth but also during tissue regeneration. ►Yorkie is hyperactive in regenerative tissue due to Warts-mediated de-repression. ►Full Yorkie activity is required for efficient wing regeneration. ►Hippo pathway-mediated tissue regeneration partially depends on Fat-Dachsous signaling.