Wound healing and blastema formation in regenerating digit tips of adult mice

► Adult digit tip regeneration in mice involves blastema formation and re-differentiation. ► Re-differentiation occurs by intramembranous ossification. ► The mouse blastema has reduced vascularity. ► Osteoclasts mediated bone degradation results in injury-induced re-amputation. ► Regeneration is imperfect and is an example of an evolved regenerative response.