کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8468211 1549572 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Challenges for modeling global gene regulatory networks during development: Insights from Drosophila
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Challenges for modeling global gene regulatory networks during development: Insights from Drosophila
چکیده انگلیسی
Development is regulated by dynamic patterns of gene expression, which are orchestrated through the action of complex gene regulatory networks (GRNs). Substantial progress has been made in modeling transcriptional regulation in recent years, including qualitative “coarse-grain” models operating at the gene level to very “fine-grain” quantitative models operating at the biophysical “transcription factor-DNA level”. Recent advances in genome-wide studies have revealed an enormous increase in the size and complexity or GRNs. Even relatively simple developmental processes can involve hundreds of regulatory molecules, with extensive interconnectivity and cooperative regulation. This leads to an explosion in the number of regulatory functions, effectively impeding Boolean-based qualitative modeling approaches. At the same time, the lack of information on the biophysical properties for the majority of transcription factors within a global network restricts quantitative approaches. In this review, we explore the current challenges in moving from modeling medium scale well-characterized networks to more poorly characterized global networks. We suggest to integrate coarse- and find-grain approaches to model gene regulatory networks in cis. We focus on two very well-studied examples from Drosophila, which likely represent typical developmental regulatory modules across metazoans.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 340, Issue 2, 15 April 2010, Pages 161-169
نویسندگان
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