کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8469980 | 1549694 | 2013 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adipocyte and adipogenesis
ترجمه فارسی عنوان
آدیپوسیت و آدیپوژنز
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
چکیده انگلیسی
Adipogenesis is the process during which fibroblast like preadipocytes developed into mature adipocytes. Adipogenesis is a well-orchestrated multistep process that requires the sequential activation of numerous transcription factors, including the CCAAT/enhancer-binding protein (C/EBP) gene family and peroxisome proliferator activated receptor-γ (PPAR-γ). In order to reach maturity, these cells must go through two vital steps: adipocyte determination and adipocyte differentiation. Although many of the molecular details of adipogenesis are still unknown, several factors involved in this processes have been identified. Some stimulators include peroxisome proliferator-activated receptor γ (PPAR γ), insulin-like growth factor I (IGF-l), macrophage colony stimulating factor, fatty acids, prostaglandins and glucocorticoids. Inhibitors include glycoproteins, transforming growth factor-β (TGF-β), inflammatory cytokines and growth hormone. Beside these factors, there are others for example age, gender and life style that may affect this process in one way or another. An increase in the number and size of adipocytes causes white adipose tissue (WAT) to expand and this can lead to obesity. Adipogenesis can lead to central obesity if it occurs in the abdominal fat depot and peripheral obesity if it occurs in subcutaneous tissue.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cell Biology - Volume 92, Issues 6â7, JuneâJuly 2013, Pages 229-236
Journal: European Journal of Cell Biology - Volume 92, Issues 6â7, JuneâJuly 2013, Pages 229-236
نویسندگان
Aus Tariq Ali, Warren E. Hochfeld, Renier Myburgh, Michael S. Pepper,