کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8470465 1549981 2018 36 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Versatility of putative aromatic aminotransferases from Candida albicans
ترجمه فارسی عنوان
فراوانی آمینوترانسفرازهای معطر آلی از کاندیدا آلبیکنس
کلمات کلیدی
آمینوترانسفرازها، نابودی ژن، کاندیدا آلبیکنس، متابولیسم آمینو اسید، هیستیدین، لیزین،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی
Amino acids constitute the key sources of nitrogen for growth of Candida albicans. In order to survive inside the host in different and rapidly changing environments, this fungus must be able to adapt via its expression of genes for amino acid metabolism. We analysed the ARO8, ARO9, YER152C, and BNA3 genes with regards to their role in the nutritional flexibility of C. albicans. CaAro8p is undoubtedly the most versatile enzyme among the aminotransferases investigated. It is involved in the catabolism of histidine, lysine, and aromatic amino acids as well as in l-Lys, Phe and Tyr biosynthesis. CaAro9p participates in the catabolism of aromatic amino acids and lysine at high concentrations of these compounds, with no biosynthetic role. Conversely, the CaYer152Cp catalytic potential for aromatic amino acid catabolism observed in vitro appears to be of little importance in vivo. Neither biosynthetic nor catabolic roles of CaBan3p were observed for any proteinogenic amino acid. Finally, none of the analysed aminotransferases was solely responsible for the catabolism of a single particular amino acid or its biosynthesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fungal Genetics and Biology - Volume 110, January 2018, Pages 26-37
نویسندگان
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