Effect of myofilament Ca2Â + sensitivity on Ca2Â + wave propagation in rat ventricular muscle

Muscle stretch increases the velocity of Ca2 + waves by increasing ROS production, not by increasing myofilament Ca2 + sensitivity. In the case of SCH00013, ROS production increases myofilament Ca2 + sensitivity and the velocity of Ca2 + waves. These results suggest that ROS rather than myofilament Ca2 + sensitivity plays an important role in the determination of the velocity of Ca2 + waves, that is, arrhythmogenesis.