کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8475037 | 1550442 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Apelin administration ameliorates high fat diet-induced cardiac hypertrophy and contractile dysfunction
ترجمه فارسی عنوان
مصرف پروتئین آپلین موجب کاهش هیپرتروفی قلب و اختلال انقباضی ناشی از رژیم غذایی بالا می شود
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
آپین، رژیم غذایی با چربی بالا، هیپرتروفی، چاقی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
چکیده انگلیسی
Apelin has been recognized as an adipokine that plays an important role in regulating energy metabolism and is credited with antiobesity and antidiabetic properties. This study was designed to examine the effect of exogenous apelin on obesity-associated cardiac dysfunction. Oral glucose tolerance test, echocardiography, cardiomyocyte contractile and intracellular Ca2Â + properties were assessed in adult C57BL/6Â J mice fed - low or a - high-fat diet for 24Â weeks followed by apelin treatment (100Â nmol/kg, i.p. for 2Â weeks). High-fat diet resulted in increased left ventricular diastolic and systolic diameters, and wall thickness, compromised fractional shortening, impaired cardiomyocyte mechanics (peak-shortening, maximal velocity of shortening/relengthening, and duration of shortening and relengthening) and compromised intracellular Ca2Â + handling, all of which were reconciled by apelin. Apelin treatment also reversed high fat diet-induced changes in intracellular Ca2Â + regulatory proteins, ER stress, and autophagy. In addition, microRNAs (miR) -133a, miR-208 and miR-1 which were elevated following high-fat feeding were attenuated by apelin treatment. In cultured cardiomyocytes apelin reconciled palmitic acid-induced cardiomyocyte contractile anomalies. Collectively, these data depict a pivotal role of apelin in obesity-associated cardiac contractile dysfunction, suggesting a therapeutic potential of apelin in the management of cardiac dysfunction associated with obesity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular and Cellular Cardiology - Volume 63, October 2013, Pages 4-13
Journal: Journal of Molecular and Cellular Cardiology - Volume 63, October 2013, Pages 4-13
نویسندگان
Asli F. Ceylan-Isik, Machender R. Kandadi, Xihui Xu, Yinan Hua, Adam J. Chicco, Jun Ren, Sreejayan Nair,