Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts

► EETs administered at ischemia or reperfusion reduce infarct size similarly. ► eNOS/NO signaling pathway mediates the cardioprotection of EETs at ischemia. ► At reperfusion, MPTP is an important mediator of the EET cardioprotective actions.