β-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets

► We model differential PKA phosphorylation kinetics of ICaL vs. IKs on transient EADs. ► A mismatch between ISO-induced ICaL and IKs increase is key for transient EADs. ► PLB dephosphorylation barely affects transient EAD1s, but reduces EAD2s. ► PLM phosphorylation attenuates transient EAD1s and EAD2s by different mechanisms.