The Ca-calmodulin dependent kinase II: A promising target for future antiarrhythmic therapies?

► Heart failure and arrhythmias are of major clinical relevance. ► CaMKII seems to be involved in both pathophysiological processes. ► CaMKII mechanisms involve effects on sarcolemmal ion channels and SR Ca handling. ► CaMKII could be a promising novel target for future antiarrhythmic therapies.