TNF receptor 1 signaling is critically involved in mediating angiotensin-II-induced cardiac fibrosis

► Joint AT1 and TNFR1 signaling is required for monocyte-to-fibroblast maturation. ► TNFR1 is involved in Ang-II-induced inflammatory and fibrotic gene transcription. ► TNFR1 is involved in Ang-II-induced non-adaptive cardiac fibrosis. ► TNFR1 is involved in Ang-II-induced cardiac remodeling and hypertension.