Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts

► Metastasis-associated protein, S100A4 modulates p53 function in cardiac fibroblasts. ► It mediates myocardial interstitial fibrosis both in vitro and in vivo. ► Two distinct mechanisms may exist; cell proliferation and collagen expression.