CypD−/− hearts have altered levels of proteins involved in Krebs cycle, branch chain amino acid degradation and pyruvate metabolism

► Identification of proteomic differences between WT and CypD-/- mice. ► CypD-/- hearts have alteration in enzymes in BCAA metabolism. ► CypD-/- hearts have alteration in in pyruvate metabolism and the Krebs cycle. ► CypD-/- hearts have altered levels of acyl carnitines.