Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophy

► Angiotensin-II induces cardiomyocyte hypertrophy in vitro via AT1 and WISP1. ► AT1 physically associates with NOX2. ► Angiotensin-II activates TCF/LEF via superoxide/Akt/GSK3β/β-catenin. ► Angiotensin-II activates CREB via Akt and superoxide-mediated p38MAPK and ERK1/2 activation. ► Angiotensin-II induced myocardial hypertrophy in vivo is associated with WISP1 upregulation.