Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice

► Myocardial autophagy is activated in insulin-resistant cardiac pathology. ► High dietary fructose induces myocardial damage, independent of hemodynamic loading. ► Suppressed Akt & BNP signaling is associated with myocyte loss in fructose feeding. ► Myocardial autophagy is a new therapeutic target in diabetic cardiopathology.