Nogo-A knockdown inhibits hypoxia/reoxygenation-induced activation of mitochondrial-dependent apoptosis in cardiomyocytes

► Nogo-A is up-regulated following hypoxic/ischemic injury. ► Nogo-A knockdown protects cardiomyocytes from hypoxia/reoxygenation-induced apoptosis. ► Nogo-A knockdown inhibits ΔΨm dissipation, ROS generation, cytochrome c release, and abnormal Ca2+ cycling.