کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8476067 1550578 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hyperplastic discs differentially regulates the transcriptional outputs of hedgehog signaling
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Hyperplastic discs differentially regulates the transcriptional outputs of hedgehog signaling
چکیده انگلیسی
Hedgehog (Hh) acts as a morphogen to activate the transcription of diverse target genes via its downstream effector Cubitus interruptus (Ci). Currently, it is less understood how Ci recruits co-factors to activate transcription. Here we report that hyperplastic discs (hyd), an E3 ubiquitin ligase, can differentially regulate the transcriptional outputs of Hh signaling. We show that loss of Hyd activity caused upregulation of some, but not all of Hh target genes. Importantly, Hyd does not affect the stability of Ci. Our data suggest that Hyd differentially restrains the transcriptional activity of Ci via selective association with respective promoters.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Development - Volume 133, August 2014, Pages 117-125
نویسندگان
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