Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver

► hhex expression in the extrahepatic duct is not affected in wnt2bb mutants. ► sox17 and sox32 are expressed in the extrahepatic duct primordium. ► Blocking Sox32 function abolishes liver formation in wnt2bb mutants. ► Fgf10a negatively impacts the regulative capacity of endodermal tissues.