Regulation of PP2A activity by Mid1 controls cranial neural crest speed and gangliogenesis

► cMid1 (expressed in r2 CNC) depletes protein phosphatase 2A (PP2A). ► cMid1 decrease/PP2A increase slow r2 CNC migration and trigeminal gangliogenesis. ► Ectopic cMid1/PP2A inhibition increase r4 CNC migration. ► PP2A decrease causes early placode neuroblast migration and facial gangliogenesis. ► PP2A inhibition in r4 CNC increases: ADAM10, migration on fibronectin or collagen.