کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8476372 1550807 2018 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Insights into the role of hepatocyte PPARα activity in response to fasting
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Insights into the role of hepatocyte PPARα activity in response to fasting
چکیده انگلیسی
Our data extended and confirmed the critical role of hepatocyte PPARα as a central for regulator of gene expression during starvation. Interestingly, we identified novel PPARα-sensitive genes, including Cxcl-10, Rab30, and Krt23. We also found that liver phospholipid remodelling was a novel fasting-sensitive pathway regulated by PPARα. These results may contribute to investigations on transcriptional control in hepatic physiology and underscore the clinical relevance of drugs that target PPARα in liver pathologies, such as non-alcoholic fatty liver disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 471, 15 August 2018, Pages 75-88
نویسندگان
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